Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

被引：8
|
作者：
Chao, Tung-Bo [1 ,2 ]
Li, Chien-Feng [3 ,4 ,5 ,6 ]
Lin, Ching-Yih [7 ,8 ]
Tian, Yu-Feng [9 ,10 ]
Chang, I-Wei [11 ]
Sheu, Ming-Jen [7 ]
Lee, Ying-En [12 ,13 ]
Chan, Ti-Chun [3 ]
He, Hong-Lin [11 ,14 ]
机构：
[1] Yuans Gen Hosp, Dept Colorectal Surg, Kaohsiung, Taiwan
[2] Meiho Univ, Dept Hlth Business Adm, Pingtung, Taiwan
[3] Chi Mei Med Ctr, Dept Pathol, Tainan, Taiwan
[4] Natl Hlth Res Inst, Natl Inst Canc Res, Tainan, Taiwan
[5] Southern Taiwan Univ Sci & Technol, Dept Biotechnol, Tainan, Taiwan
[6] Kaohsiung Med Univ, Inst Clin Med, Kaohsiung, Taiwan
[7] Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Tainan, Taiwan
[8] Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management, Tainan, Taiwan
[9] Chi Mei Med Ctr, Dept Surg, Div Gen Surg, Tainan, Taiwan
[10] Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan, Taiwan
[11] I Shou Univ, E DA Hosp, Dept Pathol, Kaohsiung, Taiwan
[12] Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol, Kaohsiung, Taiwan
[13] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan
[14] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 80424, Taiwan
来源：
FUTURE ONCOLOGY | 2016年 / 12卷 / 12期
关键词：
chemoradiotherapy; DSG3; rectal cancer; PATHOLOGICAL COMPLETE RESPONSE; TOTAL MESORECTAL EXCISION; PEMPHIGUS-VULGARIS; CELL-ADHESION; CANCER CELLS; DESMOGLEIN; NECK-CANCER; FOLLOW-UP; EXPRESSION; RADIOTHERAPY;
D O I：
10.2217/fon-2016-0071
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
引用
收藏
页码：1457 / 1467
页数：11
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