Extremely large nuchal translucency measurement predicts adverse pregnancy outcome

被引：12
|
作者：
Pitkanen, S. [1 ]
Laitinen, P. [4 ]
Yla-Outinen, A. [2 ]
Heikkila, M. [3 ]
Honkasalo, T. [1 ]
Ryynanen, M. [1 ]
Marttala, J. [1 ]
机构：
[1] Oulu Univ Hosp, Dept Obstet & Gynecol, Oys 90100, Finland
[2] Pori Cent Hosp, Pori, Finland
[3] Seinajoki Cent Hosp, Seinajoki, Finland
[4] Helsinki Univ Hosp, Dept Clin Chem & Hematol, Helsinki, Finland
来源：
JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2015年 / 35卷 / 01期
关键词：
Down syndrome; 1st trimester; nuchal translucency; singleton pregnancy; ultrasound screening; FETUSES; TRIMESTER;
D O I：
10.3109/01443615.2014.935713
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
A prospective study was conducted to determine the outcome of pregnancies with 1st trimester nuchal translucency measurement of >= 6.5 mm. The risk of fetal abnormalities increases with enlarging nuchal translucency, being around 45% with a measurement of >= 6.5 mm. A total of 27,144 women with singleton pregnancies participated in the combined Down syndrome screening within the public healthcare system in Northern Finland. The study period was 1 May 2002 to 31 May 2009. The nuchal translucency measurement was >= 6.5 mm in 16 cases (0.06%). Pregnancy outcome was normal in one case (6.3%). The risk of abnormality was higher in our study than reported in the literature. According to our study, immediate diagnostic tests should be offered after an nuchal translucency measurement of >= 6.5 mm. We should also consider analysis of fetal micro-deletions associated with certain syndromes.
引用
收藏
页码：22 / 24
页数：3
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