Extremely large nuchal translucency measurement predicts adverse pregnancy outcome

被引：12

作者：

Pitkanen, S. ^{[1
]}

Laitinen, P. ^{[4
]}

Yla-Outinen, A. ^{[2
]}

Heikkila, M. ^{[3
]}

Honkasalo, T. ^{[1
]}

Ryynanen, M. ^{[1
]}

Marttala, J. ^{[1
]}

机构：

[1] Oulu Univ Hosp, Dept Obstet & Gynecol, Oys 90100, Finland

[2] Pori Cent Hosp, Pori, Finland

[3] Seinajoki Cent Hosp, Seinajoki, Finland

[4] Helsinki Univ Hosp, Dept Clin Chem & Hematol, Helsinki, Finland

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2015年 / 35卷 / 01期

关键词：

Down syndrome; 1st trimester; nuchal translucency; singleton pregnancy; ultrasound screening; FETUSES; TRIMESTER;

D O I：

10.3109/01443615.2014.935713

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A prospective study was conducted to determine the outcome of pregnancies with 1st trimester nuchal translucency measurement of >= 6.5 mm. The risk of fetal abnormalities increases with enlarging nuchal translucency, being around 45% with a measurement of >= 6.5 mm. A total of 27,144 women with singleton pregnancies participated in the combined Down syndrome screening within the public healthcare system in Northern Finland. The study period was 1 May 2002 to 31 May 2009. The nuchal translucency measurement was >= 6.5 mm in 16 cases (0.06%). Pregnancy outcome was normal in one case (6.3%). The risk of abnormality was higher in our study than reported in the literature. According to our study, immediate diagnostic tests should be offered after an nuchal translucency measurement of >= 6.5 mm. We should also consider analysis of fetal micro-deletions associated with certain syndromes.

引用

页码：22 / 24

页数：3

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