Inhibition of bone formation in rats by aluminum exposure via Wnt/β-catenin pathway
被引:19
作者:
Sun, Xudong
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Sun, Xudong
[1
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Wang, Haoran
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Wang, Haoran
[1
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Huang, Wanyue
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Huang, Wanyue
[1
]
Yu, Hongyan
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Yu, Hongyan
[1
]
Shen, Tongtong
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Shen, Tongtong
[1
]
Song, Miao
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Song, Miao
[1
]
Han, Yanfei
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Han, Yanfei
[1
]
Li, Yanfei
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Li, Yanfei
[1
]
Zhu, Yanzhu
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Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Zhu, Yanzhu
[2
]
机构:
[1] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
[2] Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Peoples R China
The previous research found that aluminum trichloride (AlCl3) inhibited rat osteoblastic differentiation through inactivation of Wnt/beta-catenin signaling pathway in vitro. On that basis, the experiment in vivo was conducted in this study. Rats were orally exposed to 0 (control group) and 0.4 g/L AlCl3 (AlCl3-treated group) for 30, 60, 90 or 120 days, respectively. We found that mRNA expressions of type I collagen and insulin-like growth factor-1, mRNA and protein expressions of Runx2 and survivin, ratio of p-GSK3 beta/GSK3 beta and protein expression of (l-catenin were all decreased, whereas the mRNA and protein expressions Dkk1 and sFRP1 and the mRNA expressions and activity of Caspase-3 were increased in the AlCl3 treated group compared with the control group with time prolonged. These results suggest that A1Cl(3) inhibits bone formation and induces bone impairment by inhibiting the Wnt/beta-catenin signaling pathway in young growing rats. (C) 2017 Elsevier Ltd. All rights reserved.
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Bialek, P
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Kern, B
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Kern, B
;
Yang, XL
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Yang, XL
;
Schrock, M
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Schrock, M
;
Sosic, D
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Sosic, D
;
Hong, N
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Hong, N
;
Wu, H
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Wu, H
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Yu, K
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Yu, K
;
Ornitz, DM
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Ornitz, DM
;
Olson, EN
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Olson, EN
;
Justice, MJ
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机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Justice, MJ
;
Karsenty, G
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机构:
Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USABaylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
机构:
Natl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Lieu, Chien-Hui
;
Tsai, Wei-Jern
论文数: 0引用数: 0
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机构:
Natl Res Inst Chinese Med, Taipei, Taiwan
Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Tsai, Wei-Jern
;
Huang, Wen-Hsin
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机构:
Natl Def Med Ctr, Sch Pharm, Taipei, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Huang, Wen-Hsin
;
Lee, An-Rong
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机构:
Natl Def Med Ctr, Sch Pharm, Taipei, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Lee, An-Rong
;
Kuo, Yuh-Chi
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机构:
Fu Jen Catholic Univ, Dept Life Sci, Taipei, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
机构:
Univ Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, FranceUniv Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, France
Esquerre, N.
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Desreumaux, P.
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Vignal, C.
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Body-Malaper, M.
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机构:
Univ Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, FranceUniv Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, France
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Bialek, P
;
Kern, B
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Kern, B
;
Yang, XL
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Yang, XL
;
Schrock, M
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Schrock, M
;
Sosic, D
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Sosic, D
;
Hong, N
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Hong, N
;
Wu, H
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Wu, H
;
Yu, K
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Yu, K
;
Ornitz, DM
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Ornitz, DM
;
Olson, EN
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Olson, EN
;
Justice, MJ
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
Justice, MJ
;
Karsenty, G
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USABaylor Coll Med, Dept Mol & Human Genet, Bone Dis Program Texas, Houston, TX 77030 USA
机构:
Natl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Lieu, Chien-Hui
;
Tsai, Wei-Jern
论文数: 0引用数: 0
h-index: 0
机构:
Natl Res Inst Chinese Med, Taipei, Taiwan
Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Tsai, Wei-Jern
;
Huang, Wen-Hsin
论文数: 0引用数: 0
h-index: 0
机构:
Natl Def Med Ctr, Sch Pharm, Taipei, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Huang, Wen-Hsin
;
Lee, An-Rong
论文数: 0引用数: 0
h-index: 0
机构:
Natl Def Med Ctr, Sch Pharm, Taipei, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
Lee, An-Rong
;
Kuo, Yuh-Chi
论文数: 0引用数: 0
h-index: 0
机构:
Fu Jen Catholic Univ, Dept Life Sci, Taipei, TaiwanNatl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan
机构:
Univ Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, FranceUniv Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, France
Esquerre, N.
;
论文数: 引用数:
h-index:
机构:
Desreumaux, P.
;
论文数: 引用数:
h-index:
机构:
Vignal, C.
;
Body-Malaper, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, FranceUniv Lille, INSERM, CHU Lille, LIRIC Lille Inflammat Res Int Ctr U995, F-59000 Lille, France