Inhibition of bone formation in rats by aluminum exposure via Wnt/β-catenin pathway

被引：19

作者：

Sun, Xudong ^{[1
]}

Wang, Haoran ^{[1
]}

Huang, Wanyue ^{[1
]}

Yu, Hongyan ^{[1
]}

Shen, Tongtong ^{[1
]}

Song, Miao ^{[1
]}

Han, Yanfei ^{[1
]}

Li, Yanfei ^{[1
]}

Zhu, Yanzhu ^{[2
]}

机构：

[1] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China

[2] Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Peoples R China

来源：

CHEMOSPHERE | 2017年 / 176卷

关键词：

Aluminum trichloride; Bone formation; Wnt/beta-catenin signaling pathway; Rat; SIGNALING PATHWAY; OSTEOBLASTIC DIFFERENTIATION; WNT; EXPRESSION; CELLS; FLUORIDE; DISEASE; PROTEIN-1; MEMORY; DAMAGE;

D O I：

10.1016/j.chemosphere.2017.02.086

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The previous research found that aluminum trichloride (AlCl3) inhibited rat osteoblastic differentiation through inactivation of Wnt/beta-catenin signaling pathway in vitro. On that basis, the experiment in vivo was conducted in this study. Rats were orally exposed to 0 (control group) and 0.4 g/L AlCl3 (AlCl3-treated group) for 30, 60, 90 or 120 days, respectively. We found that mRNA expressions of type I collagen and insulin-like growth factor-1, mRNA and protein expressions of Runx2 and survivin, ratio of p-GSK3 beta/GSK3 beta and protein expression of (l-catenin were all decreased, whereas the mRNA and protein expressions Dkk1 and sFRP1 and the mRNA expressions and activity of Caspase-3 were increased in the AlCl3 treated group compared with the control group with time prolonged. These results suggest that A1Cl(3) inhibits bone formation and induces bone impairment by inhibiting the Wnt/beta-catenin signaling pathway in young growing rats. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

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