Pathological Relationship between Intestinal Flora and Osteoarthritis and Intervention Mechanism of Chinese Medicine

被引：10
|
作者：
Wu Yong-rong [1 ]
Kuang Gao-yan [2 ]
Lu Fang-guo [3 ]
Wang Heng-xin [4 ]
Lu Min [2 ]
Zhou Qing [1 ]
机构：
[1] Hunan Univ Chinese Med, Affiliated Hosp 1, TAN Xin Hua Famous Med Studio, Changsha 410007, Hunan, Peoples R China
[2] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Orthoped, Changsha 410007, Hunan, Peoples R China
[3] Hunan Univ Chinese Med, Dept Med Coll, Changsha 410208, Hunan, Peoples R China
[4] Hinye Pharmaceut Co Ltd, Changsha 410331, Hunan, Peoples R China
来源：
CHINESE JOURNAL OF INTEGRATIVE MEDICINE | 2019年 / 25卷 / 09期
基金：
中国国家自然科学基金;
关键词：
osteoarthritis; intestinal flora; pathogenesis; treatment; mechanism of Chinese medicine; GUT-MICROBIOTA; GASTROINTESTINAL-TRACT; OBESITY; RAT; LIPOPOLYSACCHARIDE; INTERLEUKIN-6; INFLAMMATION; EXPRESSION; HEALTH; INJURY;
D O I：
10.1007/s11655-019-3224-2
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Chinese medicine (CM) has a good clinical effect on osteoarthritis (OA), but the mechanism is not very clear. Evidence-based medicine researches have shown that intestinal flora plays a role in the pathogenesis and succession of OA. Intestinal flora affects the efficacy of CM, and CM can affect the balance of intestinal flora. This paper focuses on the relationship between intestinal flora, intestinal microenvironment, brain-gut axis, metabolic immunity and OA, and preliminarily expound the significance of intestinal flora in the pathogenesis of OA and the mechanism of CM intervention. The above discussion will be of great significance in the prevention and treatment of OA by CM from the perspective of intestinal flora.
引用
收藏
页码：716 / 720
页数：5
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