Blood dosimetry from a single measurement of the whole body radioiodine retention in patients with differentiated thyroid carcinoma

被引：57

作者：

Haenscheid, Heribert ^{[1
]}

Lassmann, Michael ^{[1
]}

Luster, Markus ^{[1
]}

Kloos, Richard T. ^{[2
,3
,4
]}

Reiners, Christoph ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Nucl Med, D-97080 Wurzburg, Germany

[2] Ohio State Univ, Dept Internal Med, Div Nucl Med, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Radiol, Div Endocrinol, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Radiol, Div Nucl Med, Columbus, OH 43210 USA

来源：

关键词：

BONE-MARROW DOSIMETRY; CANCER THERAPY; I-124; PET; I-131; BIOKINETICS; SOFTWARE;

D O I：

10.1677/ERC-09-0076

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A simple method is presented to estimate the radiation-absorbed dose to the blood after radioiodine administration from a single external measurement of the whole-body retention in patients suffering from differentiated thyroid cancer. The blood dose is calculated applying the formalism of the Medical International Radiation Dose Committee under the assumptions that whole-body activity decays exponentially and that 14% of the whole-body residence time can be attributed to the blood. Accuracy and applicability of the method were tested based on data from 29 assessments, 18 pre-therapeutic tracer studies, and 11 ablation therapies, with whole-body and blood-retention measurements over at least 4 days. The mean of the absolute deviations between estimates and actual blood doses was found to be 14%, if external whole-body counting was performed on day 1 or 2 after radioiodine administration This simple formalism is: 1) applicable to pre-therapeutic dosimetry for remnant ablation or treatment of metastases in a blood dose-based treatment concept and 2) applicable to blood-dose estimates after radioiodine therapy to determine radiation exposure. When combined with a measurement of the whole body retention 1 or 2 days after radioiodine administration this single time-point method closely approximates the classic, yet much more labor intensive multi-day dosimetry that measures both blood and whole-body activities. Endocrine-Related Cancer (2009) 16 1283-1289

引用

页码：1283 / 1289

页数：7

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