First identification of an Escherichia coli clinical isolate producing both metallo-β-lactamase VIM-2 and extended-spectrum β-lactamase IBC-1

被引：40

作者：

Galani, I ^{[1
]}

Souli, M ^{[1
]}

Chryssouli, Z ^{[1
]}

Katsala, D ^{[1
]}

Giamarellou, H ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Internal Med 4, Mol Biol Sect, GR-11527 Athens, Greece

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 08期

关键词：

bla(IBC-1); bla(VIM-2); carbapenemase; Escherichia coli; metallo-beta-lactamase; resistance;

D O I：

10.1111/j.1469-0691.2004.00913.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An Escherichia coli strain with decreased susceptibility to carbapenems was isolated from a hospitalised patient in Athens, Greece. The strain was resistant to all beta-lactarns, including aztreonam, whereas the MIC of imipenem and meropenem was 0.5 mg/L. A positive EDTA-disk synergy test suggested the production of a metallo-beta-lactamase. PCR experiments revealed the presence of the bla(VIM-2), bla(IBC-1) and bla(TEM-1) genes. Resistance to beta-lactams was not transferable by conjugation. This is the first report of a clinical isolate of E. coli producing VIM-2, and the first report of the coexistence of bla(VIM-2) and bla(IBC-1) in a single clinical isolate.

引用

页码：757 / 760

页数：4

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