Criteria for minimal model of driven polymer translocation

被引:16
作者
Suhonen, P. M. [1 ]
Kaski, K. [1 ]
Linna, R. P. [1 ]
机构
[1] Aalto Univ, Dept Biomed Engn & Computat Sci, FI-00076 Aalto, Finland
来源
PHYSICAL REVIEW E | 2014年 / 90卷 / 04期
关键词
NANOPORE; DNA; MEMBRANE; DYNAMICS; PORE;
D O I
10.1103/PhysRevE.90.042702
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
While the characteristics of the driven translocation for asymptotically long polymers are well understood, this is not the case for finite-sized polymers, which are relevant for real-world experiments and simulation studies. Most notably, the behavior of the exponent a, which describes the scaling of the translocation time with polymer length, when the driving force f(p) in the pore is changed, is under debate. By Langevin dynamics simulations of regular and modified translocation models using the freely jointed-chain polymer model we find that a previously reported incomplete model, where the trans side and fluctuations were excluded, gives rise to characteristics that are in stark contradiction with those of the complete model, for which a increases with f(p). Our results suggest that contribution due to fluctuations is important. We construct a minimal model where dynamics is completely excluded to show that close alignment with a full translocation model can be achieved. Our findings set very stringent requirements for a minimal model that is supposed to describe the driven polymer translocation correctly.
引用
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页数:8
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