Subthalamic Stimulation Improves Motor Function But Not Home and Neighborhood Mobility

被引：5

作者：

Daneault, Jean-Francois ^{[1
,2
]}

Duval, Christian ^{[2
,3
]}

Barbat-Artigas, Sebastien ^{[3
]}

Aubertin-Leheudre, Mylene ^{[3
,4
]}

Jodoin, Nicolas ^{[5
]}

Panisset, Michel ^{[5
]}

Sadikot, Abbas F. ^{[1
]}

机构：

[1] McGill Univ, Montreal Neurol Hosp & Inst, Dept Neurol & Neurosurg, Cone Lab Res Neurosurg, Montreal, PQ H3A 2B4, Canada

[2] Inst Univ Geriatr Montreal, Ctr Rech, Montreal, PQ, Canada

[3] Univ Quebec, Dept Sci Biol, Montreal, PQ H3C 3P8, Canada

[4] Univ Quebec, Dept Kinanthropol, Montreal, PQ H3C 3P8, Canada

[5] Ctr Hosp Univ Montreal, Unite Troubles Mouvement Andre Barbeau, Montreal, PQ, Canada

来源：

MOVEMENT DISORDERS | 2014年 / 29卷 / 14期

基金：

加拿大健康研究院;

关键词：

Parkinson's disease; movement disorder; STN; DBS; quality of life; life-space; DEEP-BRAIN-STIMULATION; ADVANCED PARKINSONS-DISEASE; QUALITY-OF-LIFE; NUCLEUS STIMULATION; SPACE MOBILITY; OLDER-ADULTS; APATHY; OUTCOMES; SYMPTOM; ISSUES;

D O I：

10.1002/mds.25911

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Subthalamic (STN) deep brain stimulation (DBS) is a recognized therapy for alleviating motor symptoms of Parkinson's disease (PD). However, little is known about its impact on mobility, an important component of quality of life (QoL). To address this issue, we assessed the impact of STN DBS on life-space mobility and QoL. Methods: Twenty surgical patients with PD were assessed using mobility and QoL scales and the United Parkinson's disease rating scale, and results were compared before surgery and 6 to 9 months postoperatively. Results: STN DBS significantly improved motor dysfunction but had a limited impact on measures of life-space mobility and QoL. Interpretation: STN DBS improves motor function and some components of QoL. However, motor recovery does not translate into improved life-space in the intermediate term. In addition to a focus on motor function, multidisciplinary attention to increasing mobility may further improve QoL in the intermediate and long-term. (C) 2014 International Parkinson and Movement Disorder Society

引用

页码：1816 / 1819

页数：4

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