Iridium-Catalyzed Formal [4+1] Annulation of Benzamides and Cyclopropanols to Afford Isoindolin-1-one Derivatives via C-H Activation

被引：1
|
作者：
Xu, Shuran [1 ,2 ,3 ]
Luo, Cankun [2 ,3 ]
Yan, Kaichuan [2 ,3 ]
Li, Jianglian [2 ,3 ]
Lai, Ruizhi [2 ,3 ]
Hai, Li [2 ,3 ]
Guan, Mei [1 ]
Wu, Yong [2 ,3 ]
机构：
[1] Sichuan Univ, West China Hosp, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, West China Sch Pharm, Dept Med Chem, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2022年 / 54卷 / 13期
基金：
中国国家自然科学基金;
关键词：
C-H activation; benzamides; cyclopropanols; C-N bond formation; isoindolin-1-ones; RING EXPANSION; FUNCTIONALIZATION; ARYLATION; EFFICIENT;
D O I：
10.1055/a-1780-1935
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An iridium-catalyzed reaction protocol has been developed to achieve the oxidative C-H/N-H annulation of benzamides with cyclopropanols as C1 synthon. Structurally diverse isoindolin-1-ones were furnished via sequential C-H/C-C cleavage and C-C/C-N bond formation.
引用
收藏
页码：3015 / 3024
页数：10
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