Iridium-Catalyzed Formal [4+1] Annulation of Benzamides and Cyclopropanols to Afford Isoindolin-1-one Derivatives via C-H Activation

被引：1

作者：

Xu, Shuran ^{[1
,2
,3
]}

Luo, Cankun ^{[2
,3
]}

Yan, Kaichuan ^{[2
,3
]}

Li, Jianglian ^{[2
,3
]}

Lai, Ruizhi ^{[2
,3
]}

Hai, Li ^{[2
,3
]}

Guan, Mei ^{[1
]}

Wu, Yong ^{[2
,3
]}

机构：

[1] Sichuan Univ, West China Hosp, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Sch Pharm, Dept Med Chem, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 13期

基金：

中国国家自然科学基金;

关键词：

C-H activation; benzamides; cyclopropanols; C-N bond formation; isoindolin-1-ones; RING EXPANSION; FUNCTIONALIZATION; ARYLATION; EFFICIENT;

D O I：

10.1055/a-1780-1935

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iridium-catalyzed reaction protocol has been developed to achieve the oxidative C-H/N-H annulation of benzamides with cyclopropanols as C1 synthon. Structurally diverse isoindolin-1-ones were furnished via sequential C-H/C-C cleavage and C-C/C-N bond formation.

引用

页码：3015 / 3024

页数：10

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