Rational design and biomedical applications of DNA-functionalized upconversion nanoparticles

被引：33

作者：

Liu, Xinwen ^{[1
]}

Liu, Meng ^{[1
]}

Chen, Jiajia ^{[1
]}

Li, Zhihao ^{[1
]}

Yuan, Quan ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Hubei, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Lanthanide-doped upconversion; nanoparticles; DNA; Biosensor; Bioimaging; Disease therapy; RESONANCE ENERGY-TRANSFER; PHOTON-UPCONVERTING NANOPARTICLES; SENSITIVE DETECTION; TRANSFER BIOSENSOR; DRUG-DELIVERY; LUMINESCENT NANOPARTICLES; TRANSFER APTASENSOR; LIVING CELLS; ULTRASENSITIVE DETECTION; PHOTODYNAMIC THERAPY;

D O I：

10.1016/j.cclet.2018.03.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lanthanide-doped upconversion nanoparticles (UCNPs) offer unique advantages in term of low autofluorescence, high signal-to-noise ratio and deep tissue penetration, and have attracted considerable attention in biomedical applications. DNA, beyond the properties of self-assembly, also exhibits multiple functions such as molecular recognition, drug loading capacity and therapeutic effect. In this regard, the combination of UCNPs and DNA offers a promising and powerful platform for potential applications in biosensing, bioimaging and disease therapy. In this review, we mainly introduce recent progresses of DNA-functionalized upconversion materials, providing an overview of the design and applications in biosensing, bioimaging and therapy. The challenges and future perspectives are also discussed, aiming to promote their applications in material science and biomedicine. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1321 / 1332

页数：12

共 122 条

[1] Upconversion luminescence tracking of gene delivery via multifunctional nanocapsules [J].