A B-cell activator in Chagas disease

被引：5

作者：

Kelly, JM ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, Pathogen Mol Biol & Biochem Unit, London WC1E 7HT, England

来源：

NATURE MEDICINE | 2000年 / 6卷 / 08期

关键词：

D O I：

10.1038/78618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Identification of a secreted proline racemase as a Trypanosoma cruzi B-cell mitogen provides mechanistic insight into chronic Chagas disease as well as a potential new drug target (890-897).

引用

页码：865 / 866

页数：2

共 7 条

[1] BENER Z, 1997, INT ARCH ALLERGY IMM, V114, P103
[2] DA Silva AC, 1998, IMMUNOLOGY, V94, P189, DOI 10.1046/j.1365-2567.1998.00498.x
[3] MINOPRIO P, 1991, INT IMMUNOL, V3, P427, DOI 10.1093/intimm/3.5.427
[4] MOST B-CELLS IN ACUTE TRYPANOSOMA-CRUZI INFECTION LACK PARASITE SPECIFICITY
MINOPRIO, P
BURLEN, O
PEREIRA, P
GUILBERT, B
ANDRADE, L
HONTEBEYRIEJOSKOWICZ, M
COUTINHO, A
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 28 (05) : 553 - 561
[5] A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase
Reina-San-Martín, B
Degrave, W
Rougeot, C
Cosson, A
Chamond, N
Cordeiro-Da-Silva, A
Arala-Chaves, M
Coutinho, A
Minoprio, P
[J]. NATURE MEDICINE, 2000, 6 (08) : 890 - 897
[6] ''Autoimmune rejection'' of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue
Tarleton, RL
Zhang, L
Downs, MO
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) : 3932 - 3937
[7] MOLECULAR MIMICRY BY TRYPANOSOMA-CRUZI - THE FL-160 EPITOPE THAT MIMICS MAMMALIAN NERVE CAN BE MAPPED TO A 12-AMINO ACID PEPTIDE
VANVOORHIS, WC
SCHLEKEWY, L
LETRONG, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) : 5993 - 5997

← 1 →