An expeditious and convenient synthesis of acylsulfonamides utilizing polymer-supported reagents

被引：26

作者：

Wang, Ying ^{[1
]}

Sarris, Kathy ^{[1
]}

Sauer, Daryl R. ^{[1
]}

Djuric, Stevan W. ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Med Chem Technol, High Throughput Organ Synth Grp, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 30期

关键词：

D O I：

10.1016/j.tetlet.2007.05.158

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acylsulfonamides can be rapidly and conveniently synthesized from a variety of carboxylic acids and sulfonamides utilizing the commercially available reagents, PS-DCC and DMAP under mild reaction conditions. DMAP can be efficiently scavenged by utilization of a silica-supported tosic acid cartridge (Si-SCX). In most of the cases studied, products with high purities and yields were obtained without the need for further purification. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5181 / 5184

页数：4

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