This paper considers the output feedback stabilization for a cascaded-wave PDE-ODE system with velocity recirculation by boundary control. First, we choose a well-known exponentially stable system as its target system and find a backstepping transformation to design a state feedback controller for the original system. Second, we attempt to give an output feedback controller for the original system by introducing the observer. The resulting closed-loop system admits a unique solution which is proved to be exponentially stable. Finally, we give some numerical examples to prove the validity for the theoretical results.