Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

被引：27

作者：

Foster, Caroline ^{[1
]}

Pace, Matthew ^{[2
,3
]}

Kaye, Steve ^{[1
]}

Hopkins, Emily ^{[2
]}

Jones, Mathew ^{[2
,4
]}

Robinson, Nicola ^{[2
]}

Mant, Christine ^{[3
]}

Cason, John ^{[3
]}

Fidler, Sarah ^{[1
]}

Frater, John ^{[2
,4
,5
]}

机构：

[1] Imperial Coll, Wright Fleming Inst, Div Med, London, England

[2] John Radcliffe Hosp, Nuffield Dept Clin Med, Peter Medawar Bldg Pathogen Res, Oxford, England

[3] Kings Coll London, Infect Dis BioBank, London, England

[4] Oxford Martin Sch, Inst Emerging Infect, Oxford, England

[5] Oxford Natl Inst Hlth Res, Biomed Res Ctr, Oxford, England

来源：

AIDS | 2017年 / 31卷 / 13期

基金：

英国医学研究理事会;

关键词：

early antiretroviral therapy; HIV reservoir; perinatally infected children; RESERVOIR;

D O I：

10.1097/QAD.0000000000001565

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：1847 / 1851

页数：5

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