Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality

被引：13

作者：

Diniz, Breno S. ^{[1
,2
,8
]}

Lima-Costa, Maria Fernanda ^{[3
]}

Peixoto, Sergio Viana ^{[3
,4
]}

Firmo, Joselia O. A. ^{[3
]}

Torres, Karen C. L. ^{[5
,6
]}

Martins-Filho, Olindo Assis ^{[5
]}

Teixeira-Carvalho, Andrea ^{[5
]}

Grady, James ^{[7
]}

Kuchel, George A.

Castro-Costa, Erico ^{[1
,3
]}

机构：

[1] Univ Connecticut, UConn Ctr Aging, Hlth Ctr, Farmington, CT USA

[2] Univ Connecticut, Sch Med, Dept Psychiat, Hlth Ctr, Farmington, CT USA

[3] Fundacao Oswaldo Cruz, Ctr Studies Publ Hlth & Aging NESPE, Rene Rachou Res Ctr, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Nursing Sch, Belo Horizonte, MG, Brazil

[5] Fundacao Oswaldo Cruz, Rene Rachou Res Ctr, Integrated Res Grp Biomarkers, Belo Horizonte, MG, Brazil

[6] Univ Jose Rosario Vellano, Fac Med, UNIFENAS, Belo Horizonte, MG, Brazil

[7] Univ Connecticut, Sch Med, Dept Publ Hlth Sci, Hlth Ctr, Farmington, CT USA

[8] Univ Connecticut, UConn Ctr Aging, Hlth Ctr, 263 Framington Ave,L-3091, Farmington, CT 06030 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2022年 / 30卷 / 07期

关键词：

Cognitive frailty; aging; mortality; IL-6; inflammation; MINI-MENTAL-STATE; PHYSICAL FRAILTY; BAMBUI COHORT; POPULATION; HEALTH; IMPAIRMENT; COMMUNITY; PROFILE;

D O I：

10.1016/j.jagp.2022.01.012

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Cognitive impairment and physical frailty are common among older adults and associated with a higher likelihood of adverse health outcomes. These two conditions frequently coexist in the same individual as cognitive frailty, yet few studies have examined the impact of such comorbidity on clinical outcomes or underlying biological mechanisms. Methods: A total of 1,340 older adults (age >= 60 years old) from the Bambui Cohort Study of Ageing, with a total follow-up of 10 years, were included in this study. Frailty was defined by the accumulation of deficit framework and cognitive impairment based on scores on the MMSE less than 22. In addition, serum IL-6 levels were measured by cytometric bead array assay. Results: Individuals classified with cognitive frailty had significantly higher serum IL-6 levels compared to the robust, cognitively unimpaired group. Those with cognitive frailty (aOR = 1.97 [1.18-3.271 and prefrailty and cognitive impairment (aOR = 1.83 [1.24-2.691) had the highest mortality risk over 10 years of follow-up. Higher IL-6 levels were also independently associated with a higher mortality rate (aOR = 1.37 [1.23-1.541). Conclusion: Our study shows that cognitive Frailty indicates a vulnerability state and of increasing mortality risk. Our findings also suggested

引用

页码：825 / 833

页数：9