Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities

被引：22

作者：

Glod, John ^{[4
]}

Rahme, Gilbert J. ^{[1
,3
]}

Kaur, Harpreet ^{[5
,6
,7
]}

Raabe, Eric H. ^{[5
,6
,7
]}

Hwang, Eugene I. ^{[8
,9
]}

Israel, Mark A. ^{[1
,2
,3
]}

机构：

[1] Dartmouth Coll, Hitchcock Med Ctr, Norris Cotton Canc Ctr, Dept Genet, Hanover, NH 03756 USA

[2] Dartmouth Coll, Hitchcock Med Ctr, Norris Cotton Canc Ctr, Dept Pediat, Hanover, NH 03756 USA

[3] Dartmouth Coll, Hitchcock Med Ctr, Norris Cotton Canc Ctr, Geisel Sch Med Dartmouth, Hanover, NH 03756 USA

[4] NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA

[5] Johns Hopkins Sch Med, Div Neuropathol, Bloomberg Childrens Hosp, Baltimore, MD USA

[6] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Bloomberg Childrens Hosp, Baltimore, MD USA

[7] Johns Hopkins Sch Med, Div Pediat Oncol, Bloomberg Childrens Hosp, Baltimore, MD USA

[8] Childrens Natl Med Ctr, Brain Tumor Inst, Washington, DC 20010 USA

[9] Childrens Natl Med Ctr, Div Hematol Oncol, Washington, DC 20010 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2016年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

pediatric glioma; medulloblastoma; diffuse intrinsic pontine glioma; ependymoma; SEGA; HIGH-GRADE GLIOMAS; INTRINSIC PONTINE GLIOMA; GIANT-CELL ASTROCYTOMA; MAPK PATHWAY ACTIVATION; PHASE-II; TUBEROUS SCLEROSIS; MYXOPAPILLARY EPENDYMOMA; RECURRENT EPENDYMOMA; CHILDHOOD MEDULLOBLASTOMA; MOLECULAR CLASSIFICATION;

D O I：

10.1097/MPH.0000000000000551

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Great progress has been made in many areas of pediatric oncology. However, tumors of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumors is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.

引用

页码：249 / 260

页数：12

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