Metal- and Base-Free Three-Component Reaction of Ynones, Sodium Azide, and Alkyl Halides: Highly Regioselective Synthesis of 2,4,5-Trisubstituted 1,2,3-NH-Triazoles

被引：25
作者：
Li, Jihui [1 ,2 ]
Zhang, Yuanqing [1 ,2 ]
Wang, Dong [1 ,2 ]
Wang, Wen [1 ,2 ]
Gao, Tingting [1 ,2 ]
Wang, Lu [1 ,2 ]
Li, Jiting [3 ]
Huang, Guosheng [1 ,2 ]
Chen, Baohua [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China
[3] NW Minoritise Univ, Coll Chem Engn, Lanzhou 730030, Gansu, Peoples R China
来源：
SYNLETT | 2010年 / 11期
基金：
美国国家科学基金会;
关键词：
2,4,5-trisubstituted 1,2,3-NH-triazole; three-component reaction; green chemistry; click chemistry; 1,3-DIPOLAR CYCLOADDITION REACTIONS; TERMINAL ALKYNES; EFFICIENT SYNTHESIS; CLICK CHEMISTRY; SOLID-PHASE; 1,2,3-TRIAZOLES; DERIVATIVES; INHIBITORS; ACETYLENES; TRIAZOLES;
D O I：
10.1055/s-0030-1258086
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A base- and metal-free three-component reaction of ynones, sodium azide, and alkyl halides is developed for the regioselective synthesis of 2,4,5-trisubstituted-1,2,3-triazoles. The method is general, convenient, environmentally benign, atom-economical, and high-yielding.
引用
收藏
页码：1617 / 1622
页数：6
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