Metal- and Base-Free Three-Component Reaction of Ynones, Sodium Azide, and Alkyl Halides: Highly Regioselective Synthesis of 2,4,5-Trisubstituted 1,2,3-NH-Triazoles

被引：25

作者：

Li, Jihui ^{[1
,2
]}

Zhang, Yuanqing ^{[1
,2
]}

Wang, Dong ^{[1
,2
]}

Wang, Wen ^{[1
,2
]}

Gao, Tingting ^{[1
,2
]}

Wang, Lu ^{[1
,2
]}

Li, Jiting ^{[3
]}

Huang, Guosheng ^{[1
,2
]}

Chen, Baohua ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China

[3] NW Minoritise Univ, Coll Chem Engn, Lanzhou 730030, Gansu, Peoples R China

来源：

SYNLETT | 2010年 / 11期

基金：

美国国家科学基金会;

关键词：

2,4,5-trisubstituted 1,2,3-NH-triazole; three-component reaction; green chemistry; click chemistry; 1,3-DIPOLAR CYCLOADDITION REACTIONS; TERMINAL ALKYNES; EFFICIENT SYNTHESIS; CLICK CHEMISTRY; SOLID-PHASE; 1,2,3-TRIAZOLES; DERIVATIVES; INHIBITORS; ACETYLENES; TRIAZOLES;

D O I：

10.1055/s-0030-1258086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base- and metal-free three-component reaction of ynones, sodium azide, and alkyl halides is developed for the regioselective synthesis of 2,4,5-trisubstituted-1,2,3-triazoles. The method is general, convenient, environmentally benign, atom-economical, and high-yielding.

引用

页码：1617 / 1622

页数：6

共 31 条

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