Uterine Carcinosarcomas - Diagnosis and Management

被引：38

作者：

Denschlag, Dominik ^{[1
]}

Ulrich, Uwe A. ^{[2
]}

机构：

[1] Hochtaunuskliniken Bad Homburg, Dept Gynecol, Zeppelinstr 20, D-61352 Bad Homburg, Germany

[2] Paul Gerhardt Diakonie, Martin Luther Krankenhaus, Dept Gynecol, Berlin, Germany

来源：

ONCOLOGY RESEARCH AND TREATMENT | 2018年 / 41卷 / 11期

关键词：

Chemotherapy; Endometrial cancer; Sarcoma; GYNECOLOGIC-ONCOLOGY-GROUP; PHASE-III TRIAL; MIXED MULLERIAN TUMORS; STAGE-I; PROGNOSTIC-FACTORS; UTERUS; SURVIVAL; THERAPY; SARCOMA; IFOSFAMIDE;

D O I：

10.1159/000494335

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uterine carcinosarcomas are rare tumors that account for less than 5% of all uterine malignancies. These tumors (previously called malignant mixed Mullerian tumors) are dedifferentiated carcinomas that comprise carcinomatous and sarcomatous elements and arise from a single malignant clone. They are considered a high-risk variant of endometrial adenocarcinoma because carcinosarcomas share more similarities in epidemiology, risk factors, and clinical behavior with endometrial carcinoma than with uterine sarcomas. The clinical features, diagnosis, staging, and treatment of uterine carcinosarcoma will be discussed in this review.

引用

页码：675 / 679

页数：5

共 25 条

[1] Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: A comparison with uterine endometrial adenocarcinoma [J].

Akahira, Jun-ichi ;

Tokunaga, Hideki ;

Toyoshima, Masafumi ;

Takano, Tadao ;

Nagase, Satoru ;

Yoshinaga, Kosuke ;

Tase, Toru ;

Wada, Yuichi ;

Ito, Kiyoshi ;

Niikura, Hitoshi ;

Yamada, Hidekazu ;

Sato, Akira ;

Sasano, Hironobu ;

Yaegashi, Nobuo .

ONCOLOGY, 2006, 71 (5-6) :333-340

[2] The impact of multi-modal therapy on survival for uterine carcinosarcomas [J].

Bosquet, Jesus Gonzalez ;

Terstriep, Shelby A. ;

Cliby, William A. ;

Brown-Jones, Monica ;

Kaur, Judith S. ;

Podratz, Karl C. ;

Keeney, Gary L. .

GYNECOLOGIC ONCOLOGY, 2010, 116 (03) :419-423

[3] Malignant mixed Mullerian tumors of the uterus: Analysis of patterns of failure, prognostic factors, and treatment outcome [J].

Callister, M ;

Ramondetta, LM ;

Jhingran, A ;

Burke, TW ;

Eifel, PJ .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 58 (03) :786-796

[4] A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma [J].

Cantrell, Leigh A. ;

Havrilesky, Laura ;

Moore, Dominic T. ;

O'Malley, David ;

Liotta, Margaret ;

Secord, Angeles Alvarez ;

Nagel, Christa I. ;

Cohn, David E. ;

Fader, Amanda Nickles ;

Wallace, Amy H. ;

Rose, Peter ;

Gehrig, Paola A. .

GYNECOLOGIC ONCOLOGY, 2012, 127 (01) :22-26

[5] Sarcoma of the Uterus. Guideline of the DGGG (S2k-Level, AWMF Registry No. 015/074, August 2015) (vol 75, pg 1028, 2015) [J].

Denschlag, D. ;

Thiel, F. C. ;

Ackermann, S. ;

Harter, P. ;

Juhasz-Boess, I. ;

Mallmann, P. ;

Strauss, H. -G. ;

Ulrich, U. ;

Horn, L. -C. ;

Schmidt, D. ;

Vordermark, D. ;

Vogl, T. ;

Reichardt, P. ;

Gass, P. ;

Gebhardt, M. ;

Beckmann, M. W. .

GEBURTSHILFE UND FRAUENHEILKUNDE, 2015, 75 (10) :E3-E3

[6] Impact of histology and surgical approach on survival among women with early-stage, high-grade uterine cancer: An NRG Oncology/Gynecologic Oncology Group ancillary analysis [J].

Fader, Amanda N. ;

Java, James ;

Tenney, Meaghan ;

Ricci, Stephanie ;

Gunderson, Camille C. ;

Temkin, Sarah M. ;

Spirtos, Nick ;

Kushnir, Christina L. ;

Pearl, Michael L. ;

Zivanovic, Oliver ;

Tewari, Krishnansu S. ;

O'Malley, David ;

Hartenbach, Ellen M. ;

Hamilton, Chad A. ;

Gould, Natalie S. ;

Mannel, Robert S. ;

Rodgers, William ;

Walker, Joan L. .

GYNECOLOGIC ONCOLOGY, 2016, 143 (03) :460-465

[7] Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma [J].

Galaal, Khadra ;

van der Heijden, Esther ;

Godfrey, Keith ;

Naik, Raj ;

Kucukmetin, Ali ;

Bryant, Andrew ;

Das, Nagindra ;

Lopes, Alberto D. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2013, (02)

[8] Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: A Gynecologic Oncology Group study [J].

Homesley, Howard D. ;

Filiaci, Virginia ;

Markman, Maurie ;

Bitterman, Pincas ;

Eaton, Lynne ;

Kilgore, Larry C. ;

Monk, Bradley J. ;

Ueland, Frederick R. .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (05) :526-531

[9]

Horn LC, 2009, PATHOLOGE, V30, P292, DOI 10.1007/s00292-009-1153-0

[10] Uterine Sarcoma Analysis of 13,089 Cases Based on Surveillance, Epidemiology, and End Results Database [J].

Hosh, Mona ;

Antar, Sarah ;

Nazzal, Ahmed ;

Warda, Mahmoud ;

Gibreel, Ahmed ;

Refky, Basel .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2016, 26 (06) :1098-1104

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