Reflections on the aconitine poisoning

被引:9
|
作者
Ya, Yang [2 ]
Zhixiang, Zhang [2 ]
Chao, Liu [2 ]
Wei, Zhao [2 ]
Zhiyong, Wang [2 ]
Huafeng, Cheng [3 ]
Shaohua, Zhu [2 ]
Hongfei, Xu [1 ,2 ]
机构
[1] Acad Forens Sci, Shanghai Key Lab Forens Med, Shanghai, Peoples R China
[2] Soochow Univ, Dept Forens Med, Ganjiang East Rd, Suzhou 215000, Peoples R China
[3] Funing Publ Secur Bur, Funing 224400, Peoples R China
关键词
aconitine poisoning; autopsy; forensic pathology; forensic toxicology; CHINESE HERBAL MEDICINES; QUANTITATIVE-ANALYSIS; HONG-KONG; ALKALOIDS; INVOLVEMENT;
D O I
10.1111/1556-4029.14766
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
Aconitine is a natural toxic substance belonging to the family of aconitum alkaloids, which is used in small doses by Traditional Chinese practitioners. We present a case of accidental death due to acute aconitine poisoning. A 65-year-old Chinese man presented to a medical clinic with fever and shoulder pain. Soon after administration of intravenous ceftriaxone, a bottle of Chinese medicinal wine was administered. The man rapidly experienced headache, hearing loss and tinnitus, nausea, diarrhea, numbness of the lips, tongue, face, and the upper and lower extremities, cold sweat, fall of blood pressure, and discomfort of the entire body, and he died on the same day. Postmortem examination showed cyanosis of the nail beds, severe congestion in lungs and other organs, bilateral pleural effusions, and infiltration of basophils in the intestinal submucosa. No significant increase of IgE was found in the blood. Toxicological analysis detected aconitine in the medicinal wine, blood, and stomach contents by liquid chromatography-tandem mass spectrometry (LC-MS forward slash MS). Aconitine was quantified in cardiac blood as 16.4 ng/ml, and in stomach contents (63.8 ng/ml) and wine sample (10.1 ug/ml). The cause of death was aconitine poisoning. This case report highlights the danger of aconitine. LC-MS forward slash MS has the advantages of high analytic speed, sensitivity, and accuracy. It would be desirable for the government to control the use of aconitine-containing herbal extracts.
引用
收藏
页码:2035 / 2040
页数:6
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