Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes

被引：27
作者：
Bixner, Oliver [1 ,2 ]
Kurzhals, Steffen [1 ]
Virk, Mudassar [1 ]
Reimhult, Erik [1 ]
机构：
[1] Univ Nat Resources & Life Sci, Inst Biol Inspired Mat, Dept Nanobiotechnol, Muthgasse 11, A-1190 Vienna, Austria
[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore
来源：
MATERIALS | 2016年 / 9卷 / 01期
基金：
欧洲研究理事会;
关键词：
superparamagnetic iron oxide nanoparticle; thermoresponsive polymer; magneto-polymersome; magneto-thermal release; calcein assay; BLOCK-COPOLYMER VESICLES; IRON-OXIDE NANOPARTICLES; DRUG; POLYMERIZATION; NANOCARRIERS;
D O I：
10.3390/ma9010029
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Magnetic polymersomes were prepared by self-assembly of the amphiphilic block copolymer poly(isoprene-b-N-isopropylacrylamide) with monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPION). The specifically designed thermoresponsive block copolymer allowed for efficient incorporation of the hydrophobic nanoparticles in the membrane core and encapsulation of the water soluble dye calcein in the lumen of the vesicles. Magnetic heating of the embedded SPIONs led to increased bilayer permeability through dehydration of the thermoresponsive PNIPAM block. The entrapped calcein could therefore be released in controlled doses solely through exposure to pulses of an alternating magnetic field. This hybrid SPION-polymersome system demonstrates a possible direction for release applications that merges rational polymersome design with addressed external magnetic field-triggered release through embedded nanomaterials.
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页数：14
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