Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies

被引：45

作者：

Ways, Twana Mohammed M. ^{[1
,8
]}

Filippov, Sergey K. ^{[2
,8
]}

Maji, Samarendra ^{[3
,4
]}

Glassner, Mathias ^{[3
]}

Ceglowski, Michal ^{[3
,5
]}

Hoogenboom, Richard ^{[3
]}

King, Stephen ^{[6
]}

Lau, Wing Man ^{[7
]}

Khutoryanskiy, Vitaliy V. ^{[8
]}

机构：

[1] Univ Sulaimani, Coll Pharm, Dept Pharmaceut, Sulaimani 46001, Kurdistan Regio, Iraq

[2] Abo Akad Univ, Fac Sci & Engn, Pharmaceut Sci Lab, Turku 20520, Finland

[3] Univ Ghent, Ctr Macromol Chem CMaC, Dept Organ & Macromol Chem, Supramol Chem Grp, 281 S4, B-9000 Ghent, Belgium

[4] SRM Inst Sci & Technol, Dept Chem, Kanchipuram 603203, Tamil Nadu, India

[5] Adam Mickiewicz Univ, Fac Chem, Uniwersytetu Poznanskiego 8, PL-61614 Poznan, Poland

[6] Rutherford Appleton Lab, ISIS Pulsed Neutron & Muon Source, Sci & Technol Facil Council, Harwell Campus, Didcot OX11 0QX, England

[7] Newcastle Univ, Fac Med Sci, Sch Pharm, Newcastle Upon Tyne NE1 7RU, England

[8] Univ Reading, Reading Sch Pharm, Reading RG6 6AD, England

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2022年 / 626卷

关键词：

Chitosan; Nanoparticles; Mucus penetration; Diffusion; Drug delivery; MUCOADHESIVE DRUG-DELIVERY; TRACKING ANALYSIS NTA; DOSAGE FORMS; SYSTEMS; POLYMERIZATION; PERMEABILITY; PEGYLATION; COPOLYMERS; SCATTERING; TRANSPORT;

D O I：

10.1016/j.jcis.2022.06.126

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Transmucosal administration offers numerous advantages for drug delivery as it usually helps to avoid first pass metabolism, provides rapid onset of action, and is a non-invasive route. Mucosal surfaces are covered by a viscoelastic mucus gel layer which acts as a protective barrier preventing the entrance of harmful substances into the human tissues. This function of mucus also inhibits the diffusion of drugs and nano-formulations and can result in a significant reduction of their efficacy. The design of mucuspenetrating nanoparticles can overcome the barrier function of mucus which may lead to better therapeutic outcomes. In this study, chitosan was chemically modified by grafting short chains of poly(ethylene glycol), poly(2-hydroxyethyl acrylate), poly(2-ethyl-2-oxazoline), or poly(N-vinyl pyrrolidone) and

引用

页码：251 / 264

页数：14

共 71 条

[1] PREPARATION, CHARACTERIZATION AND MUCOADHESIVE INTERACTIONS OF POLY(METHACRYLIC ACID) COPOLYMERS WITH RAT MUCOSA [J].