Memory Reconsolidation Interference as an Emerging Treatment for Emotional Disorders: Strengths, Limitations, Challenges, and Opportunities

被引：112

作者：

Beckers, Tom ^{[1
]}

Kindt, Merel ^{[2
]}

机构：

[1] Katholieke Univ Leuven, Dept Psychol, B-3000 Leuven, Belgium

[2] Univ Amsterdam, Dept Clin Psychol, NL-1018 WT Amsterdam, Netherlands

来源：

ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13 | 2017年 / 13卷

基金：

欧洲研究理事会;

关键词：

emotional memory; amnesia; reconsolidation; anxiety; PTSD; addiction; POST-RETRIEVAL PROPRANOLOL; FEAR MEMORY; RETROGRADE-AMNESIA; TRAUMA REACTIVATION; PREDICTION ERROR; TRIGGER RECONSOLIDATION; NORADRENERGIC BLOCKADE; NONEMOTIONAL MEMORIES; IMPAIRS EXTINCTION; CORTISOL RESPONSE;

D O I：

10.1146/annurev-clinpsy-032816-045209

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Experimental research on emotional memory reconsolidation interference, or the induction of amnesia for previously established emotional memory, has a long tradition, but the potential of that research for the development of novel interventions to treat psychological disorders has been recognized only recently. Here we provide an overview of basic research and clinical studies on emotional memory reconsolidation interference. We point out specific advantages of interventions based on memory reconsolidation interference over traditional treatment for emotional disorders. We also explain how findings from basic research suggest limitations and challenges to clinical translation that may help to understand why clinical trials have met with mixed success so far and how their success can be increased. In closing, we preview new intervention approaches beyond the induction of amnesia that the phenomenon of memory reconsolidation may afford for alleviating the burden imposed by emotional memories and comment on theoretical controversies regarding the nature of memory reconsolidation.

引用

页码：99 / 121

页数：23

共 118 条

[1] Disruption of Reconsolidation Erases a Fear Memory Trace in the Human Amygdala [J].

Agren, Thomas ;

Engman, Jonas ;

Frick, Andreas ;

Bjorkstrand, Johannes ;

Larsson, Elna-Marie ;

Furmark, Tomas ;

Fredrikson, Mats .

SCIENCE, 2012, 337 (6101) :1550-1552

[2] Prediction error and trace dominance determine the fate of fear memories after post-training manipulations [J].

Alfei, Joaquin M. ;

Ferrer Monti, Roque I. ;

Molina, Victor A. ;

Bueno, Adrian M. ;

Urcelay, Gonzalo P. .

LEARNING & MEMORY, 2015, 22 (08) :385-400

[3]

[Anonymous], 2003, THER BIOT PURS HAPP

[4] Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory [J].

Atsak, Piray ;

Hauer, Daniela ;

Campolongo, Patrizia ;

Schelling, Gustav ;

McGaugh, James L. ;

Roozendaal, Benno .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (09) :3504-3509

[5] Post-retrieval extinction as reconsolidation interference: methodological issues or boundary conditions? [J].

Auber, Alessia ;

Tedesco, Vincenzo ;

Jones, Carolyn E. ;

Monfils, Marie-H. ;

Chiamulera, Christian .

PSYCHOPHARMACOLOGY, 2013, 226 (04) :631-647

[6] Memory retrieval before or after extinction reduces recovery of fear in adolescent rats [J].

Baker, Kathryn D. ;

McNally, Gavan P. ;

Richardson, Rick .

LEARNING & MEMORY, 2013, 20 (09) :467-473

[7] What's wrong with fear conditioning? [J].

Beckers, Tom ;

Krypotos, Angelos-Miltiadis ;

Boddez, Yannick ;

Effting, Marieke ;

Kindt, Merel .

BIOLOGICAL PSYCHOLOGY, 2013, 92 (01) :90-96

[8] Stimulus generalization and return of fear in C57BL/6J mice [J].

Boddez, Yannick ;

Callaerts-Vegh, Zsuzsanna ;

Vervliet, Bram ;

Baeyens, Frank ;

D'Hooge, Rudi ;

Hermans, Dirk ;

Beckers, Tom .

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2012, 6

[9] Cortisol response mediates the effect of post-reactivation stress exposure on contextualization of emotional memories [J].

Bos, Marieke G. N. ;

van Goethem, Tessa H. Jacobs ;

Beckers, Tom ;

Kindt, Merel .

PSYCHONEUROENDOCRINOLOGY, 2014, 50 :72-84

[10] Stress enhances reconsolidation of declarative memory [J].

Bos, Marieke G. N. ;

Schuijer, Jantien ;

Lodestijn, Fleur ;

Beckers, Tom ;

Kindt, Merel .

PSYCHONEUROENDOCRINOLOGY, 2014, 46 :102-113

← 1 2 3 4 5 6 7 8 9 10 →