SYNTHESIS AND CYTOTOXIC ACTIVITY OF α-SANTONIN AMINO-DERIVATIVES

被引：10
|
作者：
Klochkov, S. G. [1 ]
Afanas'eva, S. V. [1 ]
Pushin, A. N. [1 ]
Gerasimova, G. K. [2 ]
Vlasenkova, N. K. [2 ]
Bulychev, Yu. N. [2 ]
机构：
[1] Russian Acad Sci, Inst Physiologically Active Cpds, Chernogolovka 142432, Moscow Oblast, Russia
[2] Russian Acad Med Sci, Res Inst Expt Tumor Diagnost & Therapy, N N Blokhin Russian Oncol Ctr, Moscow 115478, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
sesquiterpene lactone; alpha-santonin; Michael reaction; aminosantonins; cytotoxic activity; LACTONES;
D O I：
10.1007/s10600-010-9499-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Previously unknown amino-derivatives of the natural sesquiterpene lactone a-santonin were synthesized. The activity of the products against several human tumor-cell lines was studied.
引用
收藏
页码：817 / 823
页数：7
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