SYNTHESIS AND CYTOTOXIC ACTIVITY OF α-SANTONIN AMINO-DERIVATIVES

被引：10

作者：

Klochkov, S. G. ^{[1
]}

Afanas'eva, S. V. ^{[1
]}

Pushin, A. N. ^{[1
]}

Gerasimova, G. K. ^{[2
]}

Vlasenkova, N. K. ^{[2
]}

Bulychev, Yu. N. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Physiologically Active Cpds, Chernogolovka 142432, Moscow Oblast, Russia

[2] Russian Acad Med Sci, Res Inst Expt Tumor Diagnost & Therapy, N N Blokhin Russian Oncol Ctr, Moscow 115478, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

sesquiterpene lactone; alpha-santonin; Michael reaction; aminosantonins; cytotoxic activity; LACTONES;

D O I：

10.1007/s10600-010-9499-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Previously unknown amino-derivatives of the natural sesquiterpene lactone a-santonin were synthesized. The activity of the products against several human tumor-cell lines was studied.

引用

页码：817 / 823

页数：7

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