Inhibition of HIV replication by capsid mutant C6b

被引：15

作者：

Shimano, R ^{[1
]}

Iida, S ^{[1
]}

Fukumori, T ^{[1
]}

Yamamoto, Y ^{[1
]}

Kawamura, M ^{[1
]}

Furuta, RA ^{[1
]}

Adachi, A ^{[1
]}

机构：

[1] Univ Tokushima, Sch Med, Dept Virol, Tokushima 770, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 242卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.7963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A Gag capsid mutant of human immunodeficiency virus type 1 (HIV-1) designated C6b was biologically and biochemically characterized with respect to its ability to suppress the replication of wild-type (wt) HIV. The C6b efficiently interfered with the replication of wt HIV-1 in the cleavage of Gag precursor, and also in the early replication process before or during viral DNA synthesis after viral penetration. The C6b Gag appeared to be unable to form chimeric multimers with HIV-2 Gag and failed to inhibit the replication of Wt HIV-2. (C) 1998 Academic Press.

引用

页码：313 / 316

页数：4

共 17 条

[1] PRODUCTION OF ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED RETROVIRUS IN HUMAN AND NONHUMAN CELLS TRANSFECTED WITH AN INFECTIOUS MOLECULAR CLONE [J].

ADACHI, A ;

GENDELMAN, HE ;

KOENIG, S ;

FOLKS, T ;

WILLEY, R ;

RABSON, A ;

MARTIN, MA .

JOURNAL OF VIROLOGY, 1986, 59 (02) :284-291

[2]

Adachi Akio, 1996, P43

[3] THE 2-HYBRID SYSTEM - A METHOD TO IDENTIFY AND CLONE GENES FOR PROTEINS THAT INTERACT WITH A PROTEIN OF INTEREST [J].

CHIEN, CT ;

BARTEL, PL ;

STERNGLANZ, R ;

FIELDS, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9578-9582

[4] A NOVEL GENETIC SYSTEM TO DETECT PROTEIN PROTEIN INTERACTIONS [J].

FIELDS, S ;

SONG, OK .

NATURE, 1989, 340 (6230) :245-246

[5] CHARACTERIZATION OF A CONTINUOUS T-CELL LINE SUSCEPTIBLE TO THE CYTOPATHIC EFFECTS OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)-ASSOCIATED RETROVIRUS [J].

FOLKS, T ;

BENN, S ;

RABSON, A ;

THEODORE, T ;

HOGGAN, MD ;

MARTIN, M ;

LIGHTFOOTE, M ;

SELL, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) :4539-4543

[6] INTERACTION OF HTLV-1 TAX1 WITH P67(SRF) CAUSES THE ABERRANT INDUCTION OF CELLULAR IMMEDIATE EARLY GENES THROUGH CARG BOXES [J].

FUJII, M ;

TSUCHIYA, H ;

CHUHJO, T ;

AKIZAWA, T ;

SEIKI, M .

GENES & DEVELOPMENT, 1992, 6 (11) :2066-2076

[7] HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phases [J].

Furuta, RA ;

Shimano, R ;

Ogasawara, T ;

Inubushi, R ;

Amano, K ;

Akari, H ;

Hatanaka, M ;

Kawamura, M ;

Adachi, A .

FEBS LETTERS, 1997, 415 (02) :231-234

[8] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS [J].

GORMAN, CM ;

MOFFAT, LF ;

HOWARD, BH .

MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) :1044-1051

[9] GAG PROTEINS OF THE HIGHLY REPLICATIVE MN STRAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 - POSTTRANSLATIONAL MODIFICATIONS, PROTEOLYTIC PROCESSINGS, AND COMPLETE AMINO-ACID-SEQUENCES [J].

HENDERSON, LE ;

BOWERS, MA ;

SOWDER, RC ;

SERABYN, SA ;

JOHNSON, DG ;

BESS, JW ;

ARTHUR, LO ;

BRYANT, DK ;

FENSELAU, C .

JOURNAL OF VIROLOGY, 1992, 66 (04) :1856-1865

[10] HUMAN-IMMUNODEFICIENCY-VIRUS VPX IS REQUIRED FOR THE EARLY PHASE OF REPLICATION IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].

KAWAMURA, M ;

SAKAI, H ;

ADACHI, A .

MICROBIOLOGY AND IMMUNOLOGY, 1994, 38 (11) :871-878

← 1 2 →