Immunotherapy for Esophageal Squamous Cell Carcinoma

被引：58

作者：

Kojima, Takashi ^{[1
]}

Doi, Toshihiko ^{[1
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Gastroenterol & Gastrointestinal Oncol, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan

来源：

CURRENT ONCOLOGY REPORTS | 2017年 / 19卷 / 05期

关键词：

Esophageal neoplasms/TH; Immunotherapy; PHASE-II; CHECKPOINT BLOCKADE; DOUBLE-BLIND; CANCER; MULTICENTER; RECURRENT; THERAPY; 5-FLUOROURACIL; LYMPHOCYTES; IRRADIATION;

D O I：

10.1007/s11912-017-0590-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Esophageal squamous cell carcinoma have been frustrating to treat, with slow progress made on extending survival. Immunotherapy targeting immune checkpoints, T cells, and infiltrating lymphocytes has shown promise in early studies. The efficacy of pembrolizumab and nivolumab is encouraging. Anti-chemokine receptors and oncolytic viruses are also making headway against these stubborn tumors; improved results when immune checkpoint inhibitors are combined with radiation therapy are eagerly anticipated. Adoptive T cell therapy and vaccines are also under development. The importance of a multidisciplinary approach cannot be emphasized enough.

引用

页数：8

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