The Th1/Th2 paradigm in lambda cyhalothrin-induced spleen toxicity: The role of thymoquinone

被引：21
作者：
Hussein, Mohamed M. A. [1 ]
Ahmed, Mona M. [2 ]
机构：
[1] Zagazig Univ, Fac Vet Med, Dept Biochem, Zagazig 44519, Egypt
[2] Zagazig Univ, Fac Vet Med, Dept Forens Med & Toxicol, Zagazig 44519, Egypt
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 41卷
关键词：
Lambda cyhalothrin; Thymoquinone; Cytokines; RT-PCR; NF-KAPPA-B; NIGELLA-SATIVA; OXIDATIVE STRESS; IN-VIVO; RATS; GLUTATHIONE; PATHWAY; MODEL; LIVER; ACID;
D O I：
10.1016/j.etap.2015.11.008
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
This study investigates the retrofitted role of thymoquinone (TQ) in the Th1/Th2 paradigm imbalance in lambda-cyhalothrin (La) treated rats. Four groups of male Wistar rats were formed: Group I served as control. Group II received 5 mg TQ/(kg bw) daily. Group III received 0.6 mg LCT/(kg bw). Group IV was treated with TQ and LCT. All treatments were given orally for 10 weeks. The LCT-treated group elicited a significant increase in MDA and NO levels with up-regulation of NF-kappa B/p65 and pro-inflammatory genes expression and their levels. Meanwhile, GSH and immunoglobulins concentrations were markedly decreased concomitant with lessening the activities of antioxidant enzymes and anti-inflammatory cytokine genes mRNA levels. The co-administration of TQ and LCT improved the altered antioxidant enzymes activities and concentration of cytokines with attenuation of NF-kappa B/p65 mRNA. These data support the antioxidant role of TQ in the Th1/Th2 imbalance paradigm during LCT toxicity. (C) 2015 Elsevier B.V. All rights reserved.
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页码：14 / 21
页数：8
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