Potential Anti-Atherosclerotic Properties of Astaxanthin

被引：172

作者：

Kishimoto, Yoshimi ^{[1
]}

Yoshida, Hiroshi ^{[2
]}

Kondo, Kazuo ^{[1
,3
]}

机构：

[1] Ochanomizu Univ, Endowed Res Dept Food Hlth, Bunkyo Ku, 2-1-1 Otsuka, Tokyo 1128610, Japan

[2] Jikei Univ, Kashiwa Hosp, Dept Lab Med, 163-1 Kashiwashita, Kashiwa, Chiba 2778567, Japan

[3] Toyo Univ, Inst Life Innovat Studies, 1-1-1 Izumino, Itakura, Gunma 3740193, Japan

来源：

MARINE DRUGS | 2016年 / 14卷 / 02期

关键词：

astaxanthin; oxidative stress; inflammation; lipid metabolism; glucose metabolism; atherosclerosis; cardiovascular disease; LOW-DENSITY-LIPOPROTEIN; ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; MOLECULAR-MECHANISMS; ANTIOXIDANT ACTIVITY; INSULIN SENSITIVITY; PLASMA ADIPONECTIN; CHOLESTEROL EFFLUX; IMMUNE-RESPONSE; GENE-EXPRESSION;

D O I：

10.3390/md14020035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of atherosclerosis. Astaxanthin has a unique molecular structure that is responsible for its powerful antioxidant activities by quenching singlet oxygen and scavenging free radicals. Astaxanthin has been reported to inhibit low-density lipoprotein (LDL) oxidation and to increase high-density lipoprotein (HDL)-cholesterol and adiponectin levels in clinical studies. Accumulating evidence suggests that astaxanthin could exert preventive actions against atherosclerotic cardiovascular disease (CVD) via its potential to improve oxidative stress, inflammation, lipid metabolism, and glucose metabolism. In addition to identifying mechanisms of astaxanthin bioactivity by basic research, much more epidemiological and clinical evidence linking reduced CVD risk with dietary astaxanthin intake is needed.

引用

页数：13

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