Emerging Targets in Osteoporosis Disease Modification

被引:28
作者
Allen, John G. [1 ]
Fotsch, Christopher [1 ]
Babij, Philip [2 ]
机构
[1] Amgen Inc, Chem Res & Discovery, Thousand Oaks, CA 91320 USA
[2] Amgen Inc, Metab Disorders, Thousand Oaks, CA 91320 USA
关键词
CATHEPSIN-K INHIBITORS; NONPEPTIDE ALPHA(V)BETA(3) ANTAGONISTS; SENSING RECEPTOR ANTAGONIST; BONE-MINERAL DENSITY; BETA-SUBSTITUTED CYCLOHEXANECARBOXAMIDE; SELECTIVE EP4-RECEPTOR AGONIST; PHARMACOPHORE-BASED MOLECULES; AGE-RELATED OSTEOPOROSIS; SRC TYROSINE KINASE; FORMATION IN-VITRO;
D O I
10.1021/jm9018756
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:4332 / 4353
页数:22
相关论文
共 215 条
[71]   Development of high-throughput screening system for osteogenic drugs using a cell-based sensor [J].
Hojo, Hironori ;
Igawa, Kazuyo ;
Ohba, Shinsuke ;
Yano, Fumiko ;
Nakajima, Keiji ;
Komiyama, Yuske ;
Ikeda, Toshiyuki ;
Lichtler, Alexander C. ;
Woo, Je-Tae ;
Yonezawa, Takayuki ;
Takato, Tsuyoshi ;
Chung, Ung-il .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 376 (02) :375-379
[72]   1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles:: New high affinity ligands for the cannabinoid CB1 and CB2 receptors [J].
Huffman, John W. ;
Padgett, Lea W. ;
Isherwood, Matthew L. ;
Wiley, Jenny L. ;
Martin, Billy R. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (20) :5432-5435
[73]   3-(1′,1′-dimethylbutyl)-1-deoxy-Δ8-THC and related compounds:: Synthesis of selective ligands for the CB2 receptor [J].
Huffman, JW ;
Liddle, J ;
Yu, S ;
Aung, MM ;
Abood, ME ;
Wiley, JL ;
Martin, BR .
BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (12) :2905-2914
[74]   Nonpeptide αvβ3 antagonists.: 8.: In vitro and in vivo evaluation of a potent αvβ3 antagonist for the prevention and treatment of osteoporosis [J].
Hutchinson, JH ;
Hatczenko, W ;
Brashear, KM ;
Breslin, MJ ;
Coleman, PJ ;
Duong, LT ;
Fernandez-Metzler, C ;
Gentile, MA ;
Fisher, JE ;
Hartman, GD ;
Huff, JR ;
Kimmel, DB ;
Leu, CT ;
Meissner, RS ;
Merkle, K ;
Nagy, R ;
Pennypacker, B ;
Perkins, JJ ;
Prueksaritanont, T ;
Rodan, GA ;
Varga, SL ;
Wesolowski, GA ;
Zartman, AE ;
Rodan, SB ;
Duggan, ME .
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (22) :4790-4798
[75]   Regulation of Bone Mass, Osteoclast Function, and Ovariectomy-Induced Bone Loss by the Type 2 Cannabinoid Receptor [J].
Idris, Aymen I. ;
Sophocleous, Antonia ;
Landao-Bassonga, Euphemie ;
van't Hof, Robert J. ;
Ralston, Stuart H. .
ENDOCRINOLOGY, 2008, 149 (11) :5619-5626
[76]   Cannabinoid Receptor Type 1 Protects against Age-Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells [J].
Idris, Aymen I. ;
Sophocleous, Antonia ;
Landao-Bassonga, Euphemie ;
Canals, Meritxell ;
Milligan, Graeme ;
Baker, David ;
van't Hof, Robert J. ;
Ralston, Stuart H. .
CELL METABOLISM, 2009, 10 (02) :139-147
[77]   Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists.: Part 2:: Synthesis of potent αvβ3/αIIbβ3 dual antagonists [J].
Ishikawa, M ;
Kubota, D ;
Yamamoto, M ;
Kuroda, C ;
Iguchi, M ;
Koyanagi, A ;
Murakami, S ;
Ajito, K .
BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (07) :2109-2130
[78]   Synthesis of Potent αvβ3/αIIbβ3 Dual Antagonists Tricyclic Pharmaeophore-based Molecules and Their Selectivity Control [J].
Ishikawa, Minoru ;
Kubota, Dai ;
Ajito, Keiichi .
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2008, 66 (11) :1093-1104
[79]   Effects of a prostaglandin EP4 agonist, ONO-4819, and risedronate on trabecular microstructure and bone strength in mature ovariectomized rats [J].
Ito, Masako ;
Nakayama, Keiji ;
Konaka, Akira ;
Sakata, Kiyoto ;
Ikeda, Kyoji ;
Maruyama, Takayuki .
BONE, 2006, 39 (03) :453-459
[80]   Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone [J].
Jilka, RL ;
Weinstein, RS ;
Bellido, T ;
Roberson, P ;
Parfitt, AM ;
Manolagas, SC .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (04) :439-446