Propranolol, a β-adrenergic antagonist, attenuates the decrease in trabecular bone mass in high calorie diet fed growing mice

被引：9

作者：

Baek, Kyunghwa ^{[1
,2
,3
,4
]}

Hwang, Hyo Rin ^{[1
,2
]}

Park, Hyun-Jung ^{[1
,2
]}

Kwon, Arang ^{[1
,2
]}

Qadir, Abdul S. ^{[1
,2
]}

Baek, Jeong-Hwa ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Sch Dent, Dept Mol Genet, Seoul 110749, South Korea

[2] Seoul Natl Univ, Dent Res Inst, Seoul 110749, South Korea

[3] Gangneung Wonju Natl Univ, Coll Dent, Dept Pharmacol, Wonju 210702, South Korea

[4] Gangneung Wonju Natl Univ, Coll Dent, Res Inst Oral Sci, Wonju 210702, South Korea

来源：

BMB REPORTS | 2014年 / 47卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Beta-adrenergic receptor; Bone mineral density; High calorie diet; Low calorie diet; Propranolol; SYMPATHETIC-NERVOUS-SYSTEM; HIGH-FAT DIET; ENERGY RESTRICTION; LEPTIN; RATS; METABOLISM; EXERCISE; DENSITY; OBESITY; WOMEN;

D O I：

10.5483/BMBRep.2014.47.9.265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of high calorie and low calorie diets on skeletal integrity, and whether beta-adrenergic blockade (BB) attenuates bone loss induced by dietary calorie alteration. Male 6-week-old C57BL/6 mice were assigned to either an ad-lib fed control diet (CON), a high calorie diet (HIGH), or a low calorie diet (LOW) group. In each diet group, mice were treated with either vehicle (VEH) or propranolol, a beta-adrenergic antagonist. Over 12-weeks, beta-blockade mitigated body weight and fat mass increases induced by the high calorie diet. Femoral trabecular bone mineral density and the expression levels of osteogenic marker genes in bone marrow cells were reduced in HIGHVEH and LOWVEH mice, and BB significantly attenuated this decline only in HIGH mice. In summary, the magnitude of bone loss induced by low calorie diet was greater than that caused by high calorie diet in growing mice, and beta-blockade mitigated high calorie diet-induced bone loss.

引用

页码：506 / 511

页数：6

共 20 条

[1] Blocking β-adrenergic signaling attenuates reductions in circulating leptin, cancellous bone mass, and marrow adiposity seen with dietary energy restriction [J].