GEFs and GAPs: Critical elements in the control of small G proteins

被引：1401

作者：

Bos, Johannes L.

Rehmann, Holger

Wittinghofer, Alfred

机构：

[1] UMC Utrecht, Dept Physiol Chem, Utrecht, Netherlands

[2] UMC Utrecht, Ctr Biomed Genet, Utrecht, Netherlands

[3] Abt Strukturelle Biol Max Planck Inst Mol Physiol, D-44227 Dortmund, Germany

来源：

CELL | 2007年 / 129卷 / 05期

关键词：

D O I：

10.1016/j.cell.2007.05.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular functions. In general, GEFs turn on signaling by catalyzing the exchange from G-protein-bound GDP to GTP, whereas GAPs terminate signaling by inducing GTP hydrolysis. GEFs and GAPs are multidomain proteins that are regulated by extracellular signals and localized cues that control cellular events in time and space. Recent evidence suggests that these proteins may be potential therapeutic targets for developing drugs to treat various diseases, including cancer. © 2007 Elsevier Inc. All rights reserved.

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页码：865 / 877

页数：13

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