Hemodynamic Influences on abdominal aortic aneurysm disease: Application of biomechanics to aneurysm pathophysiology

被引：70

作者：

Dua, Monica M. ^{[1
]}

Dalman, Ronald L. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Div Vasc Surg, Stanford, CA 94305 USA

来源：

VASCULAR PHARMACOLOGY | 2010年 / 53卷 / 1-2期

关键词：

Abdominal aortic aneurysm; Hemodynamics; Blood flow; Inflammation; Exercise; LOWER-LIMB EXERCISE; SPINAL-CORD-INJURY; WALL SHEAR-STRESS; INDUCED ARTERIAL ENLARGEMENT; IN-VIVO QUANTIFICATION; C-REACTIVE PROTEIN; RISK-FACTORS; ENDOVASCULAR REPAIR; ENDOTHELIAL-CELLS; LOWER-EXTREMITIES;

D O I：

10.1016/j.vph.2010.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

"Atherosclerotic" abdominal aortic aneurysms (AAAs) occur with the greatest frequency in the distal aorta. The unique hemodynamic environment of this area predisposes it to site-specific degenerative changes. In this review, we summarize the differential hemodynamic influences present along the length of the abdominal aorta, and demonstrate how alterations in aortic flow and wall shear stress modify MA progression in experimental models. Improved understanding of aortic hemodynamic risk profiles provides an opportunity to modify patient activity patterns to minimize the risk of aneurysmal degeneration. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：11 / 21

页数：11

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