Magnetization Transfer Measurements of Exchange Between Hyperpolarized [1-13C]Pyruvate and [1-13C]Lactate in a Murine Lymphoma
被引:90
|
作者:
Kettunen, Mikko I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Kettunen, Mikko I.
[1
,2
]
Hu, De-en
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Hu, De-en
[1
,2
]
Witney, Timothy H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Witney, Timothy H.
[1
,2
]
McLaughlin, Rebekah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
McLaughlin, Rebekah
[1
,2
]
Gallagher, Ferdia A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, England
Univ Cambridge, Dept Radiol, Addenbrookes Hosp, Cambridge CB2 1GA, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Gallagher, Ferdia A.
[1
,2
,3
]
Bohndiek, Sarah E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Bohndiek, Sarah E.
[1
,2
]
Day, Sam E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Day, Sam E.
[1
,2
]
Brindle, Kevin M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, EnglandUniv Cambridge, Dept Biochem, Cambridge CB2 1GA, England
Brindle, Kevin M.
[1
,2
]
机构:
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
[2] Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, England
Measurements of the conversion of hyperpolarized [1-C-13]pyruvate into lactate, in the reaction catalyzed by lactate dehydrogenase, have shown promise as a metabolic marker for the presence of disease and response to treatment. However, it is unclear whether this represents net flux of label from pyruvate to lactate or exchange of isotope between metabolites that are close to chemical equilibrium. Using saturation and inversion transfer experiments, we show that there is significant exchange of label between lactate and pyruvate in a murine lymphoma in vivo. The rate constants estimated from the magnetization transfer experiments, at specific points during the time course of label exchange, were similar to those obtained by fitting the changes in peak intensities during the entire exchange time course to a kinetic model for two-site exchange. These magnetization transfer experiments may therefore provide an alternative and more rapid way of estimating flux between pyruvate and lactate to serial measurements of pyruvate and lactate C-13 peak intensities following injection of hyperpolarized [1-C-13]pyruvate. Magn Reson Med 63:872-880,2010. (C) 2010 Wiley-Liss, Inc.
机构:
Univ Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA
Perkons, Nicholas R.
Johnson, Omar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA
Univ Penn, Dept Radiol, Philadelphia, PA 19104 USAUniv Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA
Johnson, Omar
Pilla, Gabrielle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA
Pilla, Gabrielle
Gade, Terence P. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA
Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
Univ Penn, Dept Canc Biol, Philadelphia, PA 19104 USAUniv Penn, Penn Image Guided Intervent Lab, Philadelphia, PA 19104 USA