共 18 条
Primary Tumor Resection in Patients Presenting With Metastatic Colorectal Cancer Analysis of a Provincial Population-Based Cohort
被引:22
作者:

Chan, Theresa W.
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机构:
British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada

Brown, Carl
论文数: 0 引用数: 0
h-index: 0
机构:
St Pauls Hosp, Dept Surg, Vancouver, BC V6Z 1Y6, Canada British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada

Ho, Cheryl C.
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h-index: 0
机构:
British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada

Gill, Sharlene
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机构:
British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada
机构:
[1] British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada
[2] St Pauls Hosp, Dept Surg, Vancouver, BC V6Z 1Y6, Canada
来源:
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
|
2010年
/
33卷
/
01期
关键词:
primary resection;
metastatic colorectal cancer;
FLUOROURACIL;
LEUCOVORIN;
SURVIVAL;
OXALIPLATIN;
COMBINATION;
BEVACIZUMAB;
IRINOTECAN;
SURGERY;
DISEASE;
D O I:
10.1097/COC.0b013e31819e902d
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Purpose: We conducted a Canadian population-based study to assess surgical practice patterns and outcomes among patients with metastatic colorectal cancer (mCRC) at diagnosis. Methods: We reviewed a provincial cancer registry for 2 years. Four hundred eleven patients presenting with mCRC were stratified by primary tumor resection Status. Baseline characteristics, treatment modalities, and outcomes were assessed. Results: Seventy percent of patients underwent resection. Resected patients were less likely to have rectal primaries (16% vs. 42%, P <= 0.001) and had more obstructive symptoms (47% vs. 31%, P <= 0.001) or bleeding (26% vs. 6%. P <= 0.001). They experienced fewer tumor-related complications (4% vs. 22%, P <= 0.001). Use of first-line chemotherapy was similar (61%, vs. 58%, P = 0.54). but the resection cohort was more likely to receive doublet chemotherapy (57% vs. 36%, P <= 0.01) and metastatectomy (10% vs. 0%, P <= 0.0001). Among patients with rectal tumors, radiation use was comparable (63% vs 58%, P = 0.68). Median survival was longer in the resection group (14 vs. 6 months, P <= 0.001). Conclusions: Most patients presenting with mCRC underwent primary resection. Colonic tumors, obstruction, and bleeding were associated with resection. In situ primaries conferred more complications. despite similar use of radiation in cases of rectal cancer. Unresected patients were less likely to receive doublet chemotherapy or metastatectomy, and had inferior survival.
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页码:52 / 55
页数:4
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