Clear Cell Hepatocellular Carcinoma Diagnosed by Bile Duct Brushing Cytology

被引:6
作者
Fu, Li-Ying [1 ]
Mitchell, Kisha A. [1 ]
Cai, Guoiping [1 ]
机构
[1] Yale Univ, Sch Med, Dept Pathol, 310 Cedar St,CB506B, New Haven, CT 06510 USA
关键词
clear cell hepatocellular carcinoma; bile duct brushing; cytology; immunocytochemistry; BILIARY; LIVER; CHOLANGIOCARCINOMA; CYTOMORPHOLOGY; ANGIOMYOLIPOMA; CYTODIAGNOSIS;
D O I
10.1002/dc.23397
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Clear cell hepatocellular carcinoma (CCHCC) is an uncommon morphologic variant of HCC and rarely invades into the main bile ducts. Here we describe a case of CCHCC that was diagnosed by bile duct brushing cytology. Liquid-based preparation of brushing specimen showed clusters of atypical epithelial cells with abundant clear cytoplasm, round nuclei, and occasional intranuclear inclusions. The tumor cells were positive for HepPar-1 and arginase 1, suggestive of their hepatic origin. The overall morphologic and immunophenotypic features were consistent with CCHCC. The cytological diagnosis was confirmed by histopathologic examination of the resected tumor. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:147 / 151
页数:5
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