Identification of hepatitis B virus genotype A/E recombinants in Ghana

被引：4
作者：
Boyce, Ceejay L. [1 ]
Willis, Stephaney [1 ]
Archampong, Timothy N. A. [2 ,3 ]
Lartey, Margaret [2 ,3 ]
Sagoe, Kwamena W. [4 ]
Obo-Akwa, Adjoa [2 ]
Kenu, Ernest [3 ,5 ]
Kwara, Awewura [6 ]
Blackard, Jason T. [1 ]
机构：
[1] Univ Cincinnati, Coll Med, Div Digest Dis, Cincinnati, OH 45267 USA
[2] Univ Ghana, Coll Hlth Sci, Sch Med & Dent, Dept Med & Therapeut, Accra, Ghana
[3] Korle Bu Teaching Hosp, Accra, Ghana
[4] Univ Ghana, Coll Hlth Sci, Sch Biomed & Allied Hlth Sci, Dept Med Microbiol, Accra, Ghana
[5] Univ Ghana, Coll Hlth Sci, Sch Publ Hlth, Accra, Ghana
[6] Univ Florida, Div Infect Dis & Global Med, Gainesville, FL USA
来源：
VIRUS GENES | 2019年 / 55卷 / 05期
关键词：
Hepatitis B virus; Genotype; Recombinant; recombination; Africa; Ghana; ASYMPTOMATIC BLOOD-DONORS; GENETIC DIVERSITY; SUBGENOTYPE A3; HBV GENOTYPES; GENOMES;
D O I：
10.1007/s11262-019-01690-y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Hepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identified as genotype A4. Full-length HBV genomes were obtained using rolling circle amplification followed by PCR and shown to cluster with known A/E recombinant viruses. Similar recombination breakpoints were observed in these three individuals suggesting local spread of this novel recombinant HBV in Ghana.
引用
收藏
页码：707 / 712
页数：6
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