Identification of hepatitis B virus genotype A/E recombinants in Ghana

被引：4

作者：

Boyce, Ceejay L. ^{[1
]}

Willis, Stephaney ^{[1
]}

Archampong, Timothy N. A. ^{[2
,3
]}

Lartey, Margaret ^{[2
,3
]}

Sagoe, Kwamena W. ^{[4
]}

Obo-Akwa, Adjoa ^{[2
]}

Kenu, Ernest ^{[3
,5
]}

Kwara, Awewura ^{[6
]}

Blackard, Jason T. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Div Digest Dis, Cincinnati, OH 45267 USA

[2] Univ Ghana, Coll Hlth Sci, Sch Med & Dent, Dept Med & Therapeut, Accra, Ghana

[3] Korle Bu Teaching Hosp, Accra, Ghana

[4] Univ Ghana, Coll Hlth Sci, Sch Biomed & Allied Hlth Sci, Dept Med Microbiol, Accra, Ghana

[5] Univ Ghana, Coll Hlth Sci, Sch Publ Hlth, Accra, Ghana

[6] Univ Florida, Div Infect Dis & Global Med, Gainesville, FL USA

来源：

VIRUS GENES | 2019年 / 55卷 / 05期

关键词：

Hepatitis B virus; Genotype; Recombinant; recombination; Africa; Ghana; ASYMPTOMATIC BLOOD-DONORS; GENETIC DIVERSITY; SUBGENOTYPE A3; HBV GENOTYPES; GENOMES;

D O I：

10.1007/s11262-019-01690-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Hepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identified as genotype A4. Full-length HBV genomes were obtained using rolling circle amplification followed by PCR and shown to cluster with known A/E recombinant viruses. Similar recombination breakpoints were observed in these three individuals suggesting local spread of this novel recombinant HBV in Ghana.

引用

页码：707 / 712

页数：6

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