Microcalorimetry of biological macromolecules

被引：128
|
作者：
Privalov, Peter L. [1 ]
Dragan, Anatoly I. [1 ]
机构：
[1] Johns Hopkins Univ, Baltimore, MD 21218 USA
来源：
BIOPHYSICAL CHEMISTRY | 2007年 / 126卷 / 1-3期
关键词：
microcalorimetry; thermodynamics; proteins; DNA; unfolding; association; hydration;
D O I：
10.1016/j.bpc.2006.05.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The capabilities of contemporary differential scanning and isothermal titration microcalorimetry for studying the thermodynamics of protein unfolding/refolding and their association with partners, particularly target DNA duplexes, are considered. It is shown that the predenaturational changes of proteins must not be ignored in studying the thermodynamics of formation of their native structure and their complexes with partners, particularly their cognate DNA duplexes. (c) 2006 Elsevier B.V. All rights reserved.
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收藏
页码：16 / 24
页数：9
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