High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes

被引：16

作者：

Berg, T

Vandersteen, AM

Janda, KD

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(98)00199-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 'combinatorial catalysis' strategy was utilized to both rapidly synthesize organometallic complexes and to screen them for catalytic activity in chemical reactions. The application of this strategy has yielded several metal-complexes that catalyze the hydrolysis of carboxylic acid esters efficiently. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1221 / 1224

页数：4

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