The role m6A RNA methylation is CNS development and glioma pathogenesis

被引：31

作者：

Pan, Ting ^{[1
,2
]}

Wu, Fan ^{[1
]}

Li, Liwen ^{[3
,4
]}

Wu, Shiyan ^{[1
,2
]}

Zhou, Fang ^{[1
,2
]}

Zhang, Ping ^{[2
]}

Sun, Caixing ^{[3
,4
]}

Xia, Liang ^{[3
,4
]}

机构：

[1] Zhejiang Chinese Med Univ, Sch Clin Med Coll 2, Hangzhou 310053, Peoples R China

[2] Univ Chinese Acad Sci, Chinese Acad Sci, Zhejiang Canc Hosp, Dept Gynecol Oncol,Canc Hosp,Inst Basic Med & Can, Hangzhou 310022, Peoples R China

[3] Univ Chinese Acad Sci, Chinese Acad Sci, Zhejiang Canc Hosp, Dept Neurosurg,Canc Hosp,Inst Basic Med & Canc IB, Hangzhou 310022, Peoples R China

[4] Translat Res Zhejiang Prov, Key Lab Head & Neck Canc, Hangzhou 310022, Peoples R China

来源：

MOLECULAR BRAIN | 2021年 / 14卷 / 01期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

Glioma; GBM; m(6)A methylation; METTL3; WTAP; ALKBH5; FTO; STEM-LIKE CELLS; MESSENGER-RNA; DEMETHYLASE ALKBH5; GENE-EXPRESSION; NUCLEAR-RNA; N6-METHYLADENOSINE; GLIOBLASTOMA; REVEALS; NUCLEOSIDES; PREDICTS;

D O I：

10.1186/s13041-021-00831-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification. m(6)A methylation is the most common and most intensively studied RNA methylation, which can be found throughout the RNA life cycle and exert biological functions by affecting RNA metabolism. The m(6)A modification is primarily associated with three types of protease, which are encoded by the writer, eraser and reader genes, respectively. It has been shown that the m(6)A methylation has close connections with the occurrence and development of many tumors, including glioma. In this study, the concept and the research progress of m(6)A methylation are reviewed, especially the role of m(6)A methylation in glioma. Moreover, we will discuss how glioma is paving the way to the development of new therapeutic options based on the inhibition of m(6)A deposition.

引用

页数：9

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