Photobiomodulation induces murine macrophages polarization toward M2 phenotype

被引：12

作者：

Reis, Valdison P. ^{[1
]}

Paloschi, Mauro, V ^{[1
]}

Rego, Cristina M. A. ^{[1
]}

Tavares, Maria Naiara M. ^{[1
]}

Boeno, Charles N. ^{[1
]}

Lopes, Jessica A. ^{[1
]}

Ferreira E Ferreira, Alex A. ^{[1
]}

Soares, Andreimar M. ^{[2
,3
,4
]}

Zamuner, Stella R. ^{[5
]}

Zuliani, Juliana P. ^{[1
,2
,3
]}

机构：

[1] FIOCRUZ Rondonia, Lab Imunol Cellular Aplicada Saude, Rua Beira,7671 BR364,Km 3,5, BR-76812245 Porto Velho, RO, Brazil

[2] Univ Fed Rondonia, UNIR, Dept Med, Ctr Estudos Biomol Aplicadas Saude,CEBio, Porto Velho, RO, Brazil

[3] FIOCRUZ Rondonia, Porto Velho, RO, Brazil

[4] UNISL, Ctr Univ Sao Lucas, Porto Velho, RO, Brazil

[5] Univ Nove Julho, UNINOVE, Sao Paulo, SP, Brazil

来源：

TOXICON | 2021年 / 198卷

关键词：

Bothrops jararacussu venom; Macrophages; Light emitting diode; Photobiomodulation; BOTHROPS-ASPER VENOM; ACTIVATION;

D O I：

10.1016/j.toxicon.2021.05.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effective therapeutic associated with serum therapy for local treatment of snakebites. Here we explored the effects of LED treatment on isolated macrophage under Bothrops jararacussu venom. Results showed that LED induced IL-6 and TNF-alpha genes down-regulation and, TGF and ARG1 genes up-regulation which indicates a polarization of macrophages to an M2 phenotype contributing to both tissue repair and resolution of inflammation.

引用

页码：171 / 175

页数：5

共 33 条

[1] Engineering Venom's Toxin-Neutralizing Antibody Fragments and Its Therapeutic Potential [J].

Alvarenga, Larissa M. ;

Zahid, Muhammad ;

di Tommaso, Anne ;

Juste, Matthieu O. ;

Aubrey, Nicolas ;

Billiald, Philippe ;

Muzard, Julien .

TOXINS, 2014, 6 (08) :2541-2567

[2] Biostimulation effects of low-power laser in the repair process [J].

Alves Uchoa Lins, Ruthineia Diogenes ;

Dantas, Euler Maciel ;

Raposo Lucena, Keila Cristina ;

Chaves Vasconcelos Catao, Maria Helena ;

Granville-Garcia, Ana Flavia ;

Carvalho Neto, Luiz Guedes .

ANAIS BRASILEIROS DE DERMATOLOGIA, 2010, 85 (06) :849-855

[3]

Arrese Estela L, 2014, Lipid Insights, V7, P7

[4]

BALDO Marcus., 2003, Revi Bras Psiquiatr, P6

[5] Effect of Low-Level Laser Therapy in the Myonecrosis Induced by Bothrops jararacussu Snake Venom [J].

Barbosa, Ana Maria ;

Villaverde, Antonio Balbin ;

Sousa, Ludmila Guimaraes ;

Munin, Egberto ;

Fernandez, Cristina Maria ;

Cogo, Jose Carlos ;

Zamuner, Stella Regina .

PHOTOMEDICINE AND LASER SURGERY, 2009, 27 (04) :591-597

[6] Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization [J].

Diaz-Bulnes, Paula ;

Laura Saiz, Maria ;

Lopez-Larrea, Carlos ;

Rodriguez, Ramon M. .

FRONTIERS IN IMMUNOLOGY, 2020, 10

[7] Light emitting diode (LED) photobiomodulation therapy on murine macrophage exposed to Bothropstoxin-I and Bothropstoxin-II myotoxins [J].

dos Reis, Valdison Pereira ;

Macedo Tavares, Maria Naiara ;

Alves Rego, Cristina Matiele ;

Augusto Ferreira e Ferreira, Alex ;

Setubal, Sulamita da Silva ;

Soares, Andreimar Martins ;

Zamuner, Stella Regina ;

Zuliani, Juliana Pavan .

TOXICON, 2019, 172 :45-52

[8] Activation of J77A.1 Macrophages by Three Phospholipases A2 Isolated from Bothrops atrox Snake Venom [J].

Furtado, Juliana L. ;

Oliveira, George A. ;

Pontes, Adriana S. ;

Setubal, Sulamita da S. ;

Xavier, Caroline V. ;

Lacouth-Silva, Fabianne ;

Lima, Beatriz F. ;

Zaqueo, Kayena D. ;

Kayano, Anderson M. ;

Calderon, Leonardo A. ;

Stabeli, Rodrigo G. ;

Soares, Andreimar M. ;

Zuliani, Juliana P. .

BIOMED RESEARCH INTERNATIONAL, 2014, 2014

[9] The lipid droplet-a well-connected organelle [J].

Gao, Qiang ;

Goodman, Joel M. .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2015, 3

[10] A snake venom group IIA PLA2 with immunomodulatory activity induces formation of lipid droplets containing 15-d-PGJ2 in macrophages [J].

Giannotti, Karina Cristina ;

Leiguez, Elbio ;

Zulim de Carvalho, Ana Eduarda ;

Nascimento, Neide Galvao ;

Matsubara, Marcio Hideki ;

Fortes-Dias, Consuelo Latorre ;

Moreira, Vanessa ;

Teixeira, Catarina .

SCIENTIFIC REPORTS, 2017, 7

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