Homologous recombination and the repair of DNA double-strand breaks

被引：475

作者：

Wright, William Douglass ^{[1
]}

Shah, Shanaya Shital ^{[1
]}

Heyer, Wolf-Dietrich ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Dept Microbiol & Mol Genet, One Shields Ave, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2018年 / 293卷 / 27期

基金：

美国国家卫生研究院;

关键词：

genomic instability; DNA recombination; DNA repair; DNA topology; DNA damage; DNA endonuclease; DNA helicase; DNA polymerase; DNA topoisomerase; RAD51 FILAMENT FORMATION; REPLICATION PROTEIN-A; GENE CONVERSION TRACTS; COLI RECA-PROTEIN; SACCHAROMYCES-CEREVISIAE; ATP HYDROLYSIS; PRESYNAPTIC FILAMENT; NUCLEOPROTEIN FILAMENTS; ESCHERICHIA-COLI; MITOTIC RECOMBINATION;

D O I：

10.1074/jbc.TM118.000372

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix. Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the context of the repair of DNA double-strand breaks in somatic cells. This includes homology search, DNA strand invasion, repair DNA synthesis, and restoration of intact chromosomes. Aspects of DNA topology affecting individual steps are highlighted. Overall, recombination is a dynamic pathway with multiple metastable and reversible intermediates designed to achieve DNA repair with high fidelity.

引用

页码：10524 / 10535

页数：12

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