Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in patients with restless legs syndrome

被引:5
作者
Halac, G. [1 ]
Kilic, E. [1 ,2 ]
Cikrikcioglu, M. A. [1 ,3 ]
Celik, K. [1 ,3 ]
Toprak-Erek, A. [1 ,4 ]
Keskin, S. [1 ,2 ]
Gultepe, I [1 ,3 ]
Celik, R. S. [1 ,3 ]
Ozaras, N. [1 ,5 ]
Yildiz, A. [1 ,6 ]
Aydin, S. [1 ,7 ]
Akan, O. [1 ,8 ]
Karatoprak, C. [1 ,3 ]
Sekin, Y. [1 ,3 ]
Asil, T. [1 ]
机构
[1] Bezmi Alem Vakif Univ, Dept Neurol, Fac Med, Istanbul, Turkey
[2] Bezmi Alem Vakif Univ, Dept Clin Biochem, Fac Med, Istanbul, Turkey
[3] Bezmi Alem Vakif Univ, Dept Internal Med, Fac Med, Istanbul, Turkey
[4] Istanbul Medeniyet Univ, Dept Biochem, Fac Med, Istanbul, Turkey
[5] Bezmi Alem Vakif Univ, Dept Phys Med & Rehabil, Fac Med, Istanbul, Turkey
[6] Dicle Univ, Dept Cardiol, Fac Med, Diyarbakir, Turkey
[7] Yedikule Chest Dis & Thorax Surg Educ & Res Hosp, Dept Neurol, Istanbul, Turkey
[8] Okmeydani Educ & Res Hosp, Dept Neurol, Istanbul, Turkey
来源
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2016年 / 117卷 / 06期
关键词
restless legs syndrome; atherosclerosis; sLOX-1; CARDIOVASCULAR-DISEASE; HEART-DISEASE; RISK-FACTORS; PREVALENCE; WOMEN; ATHEROSCLEROSIS; DIAGNOSIS; MARKER;
D O I
10.4149/BLL_2016_063
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: The aim of this study was to assess the predisposition for atherosclerosis in patients with RLS through serum sLOX-1 (serum Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) measurements. BACKGROUND: Recent epidemiological studies have suggested an association of RLS with certain chronic conditions such as diabetes mellitus (DM), obesity, hypertension (HT), and hyperlipidemia. LOX-1 is expressed in endothelial cells, macrophages, and in smooth muscle cells under the effect of proatherogenic conditions. METHODS: This study was a prospective, cross-sectional, case-controlled. We measured the serum sLOX-1 levels in 37 restless legs syndrome patients and 38 controls. RESULTS: Serum sLOX-1 level was significantly lower in the patient group. The two groups were similar in glucose, HbA1c, creatinine, LDL cholesterol, TG, HDL, total protein, albumin, AST, ALT, GGT, ALP, HGB, HCT, MCV, transferrin saturation rate (TSR), ferritin, CRP, TSH, FT4, FT3, B12, and folic acid levels. Also the two groups were similar with respect to age at menarche, number of previous births, number of abortions and/or curettage, total duration of breastfeeding, percentage of patients in menopause, and age at menopause. CONCLUSION: Our results may suggest a lower atherosclerotic risk among RLS patients as compared to the general population (Tab. 3, Ref. 33). Text in PDF www.elis.sk.
引用
收藏
页码:316 / 320
页数:5
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