Value of methylation markers in colorectal cancer

被引：9
|
作者：
Kong, Can [1 ]
Fu, Tao [1 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Gastrointestinal Surg 2, 238 Jiefang Rd,Huanghelou St, Wuhan 430060, Hubei, Peoples R China
来源：
ONCOLOGY REPORTS | 2021年 / 46卷 / 02期
关键词：
DNA methylation; colorectal cancer; epigenetics; MUTL HOMOLOG 1; DNA METHYLATION; PROMOTER METHYLATION; EPIGENETIC ALTERATIONS; LINE-1; METHYLATION; RASSF1A PROMOTER; STAGE-II; STOOL; HYPERMETHYLATION; GENE;
D O I：
10.3892/or.2021.8128
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) is a multifactorial and multistage process that occurs due to both genetic and epigenetic variations in normal epithelial cells. Analysis of the CRC epigenome has revealed that almost all CRC types have a large number of abnormally methylated genes. Hypermethylation of cell-free DNA from CRC in the blood or stool is considered as a potential non-invasive cancer biomarker, and various methylation markers have shown high sensitivity and specificity. The aim of the present review was to examine potential methylation markers in CRC that have been used or are expected to be used in the clinical setting, focusing on their screening, predictive, prognostic and therapeutic roles in CRC.
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页数：12
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