Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells

被引：82

作者：

Cheng, Xin-Rui

Zhang, Li

Hu, Juan-Juan

Sun, Lan ^{[1
]}

Du, Guan-Hua

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pharmacol, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Natl Ctr Pharmaceut Screening, Beijing 100005, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2007年 / 31卷 / 05期

基金：

中国国家自然科学基金;

关键词：

tetramethylpyrazine; PC12; cells; hydrogen peroxide; apoptosis; mitochondria;

D O I：

10.1016/j.cellbi.2006.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the present study, we investigated the effects of tetramethylpyrazine (TMP) on hydrogen peroxide (H2O2)-induced apoptosis in PC12 cells. The apoptosis in H2O2-induced PC12 cells was accompanied by a decrease in Bcl-2/Bax protein ratio, release of cytochrome c to cytosol and the activation of caspase-3. TMP not only suppressed the down-regulation of Bcl-2, up-regulation of Bax and the release of mitochondrial cytochrome c to cytosol, but also attenuated caspase-3 activation and eventually protected against H2O2-induced apoptosis. These results indicated that TMP blocked H2O2-induced apoptosis by the regulation of Bcl-2 family members, suppression of cytochrome c release, and caspase cascade activation in PC12 cells. (C) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：438 / 443

页数：6

共 25 条

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