Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells

被引：81
|
作者：
Cheng, Xin-Rui
Zhang, Li
Hu, Juan-Juan
Sun, Lan [1 ]
Du, Guan-Hua
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pharmacol, Beijing 100005, Peoples R China
[2] Peking Union Med Coll, Beijing 100005, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, Natl Ctr Pharmaceut Screening, Beijing 100005, Peoples R China
来源：
CELL BIOLOGY INTERNATIONAL | 2007年 / 31卷 / 05期
基金：
中国国家自然科学基金;
关键词：
tetramethylpyrazine; PC12; cells; hydrogen peroxide; apoptosis; mitochondria;
D O I：
10.1016/j.cellbi.2006.10.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the present study, we investigated the effects of tetramethylpyrazine (TMP) on hydrogen peroxide (H2O2)-induced apoptosis in PC12 cells. The apoptosis in H2O2-induced PC12 cells was accompanied by a decrease in Bcl-2/Bax protein ratio, release of cytochrome c to cytosol and the activation of caspase-3. TMP not only suppressed the down-regulation of Bcl-2, up-regulation of Bax and the release of mitochondrial cytochrome c to cytosol, but also attenuated caspase-3 activation and eventually protected against H2O2-induced apoptosis. These results indicated that TMP blocked H2O2-induced apoptosis by the regulation of Bcl-2 family members, suppression of cytochrome c release, and caspase cascade activation in PC12 cells. (C) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：438 / 443
页数：6
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