A new one-step synthesis of 1,2,4-triazino[2,3-c]quinazolines

被引：0

作者：

Karpenko, Oleksandr V.

Kovalenko, Sergiy I.

Chekotylo, Oleksiy O.

Shishkina, Svitlana V.

机构：

[1] Zaporizhzhia State Med Univ, Dept Pharmaceut Chem, UA-69035 Zaporizhzhia, Ukraine

[2] Enamine Ltd, UA-01103 Kiev, Ukraine

[3] Natl Acad Sci Ukraine, STC Inst Single Crystals, UA-61001 Kharkov, Ukraine

来源：

HETEROCYCLES | 2007年 / 71卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient one-step protocol for the synthesis of 3-substituted 2H-1,2,4-triazino[2,3-c]quinazolin-2-ones (5) was developed starting from 4-hydrazinoquinazoline (1) and alpha-ketocarboxylic acids and their esters. Corresponding hydrazones (2a,c and 3a,c,e) were isolated as intermediate products. Further cyclocondensation followed by acid-catalyzed Dimroth rearrangement resulted in the title derivatives 5.

引用

页码：619 / 626

页数：8

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