Two new biologically active illudane sesquiterpenes from the mycelial cultures of Panaeolus redrugis

被引：14

作者：

Ma, WZ

Huang, YC

Lin, LD

Zhu, XF

Chen, YZ

Xu, HH

Wei, XY ^{[1
]}

机构：

[1] Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, Beijing 10080, Peoples R China

[3] Sun Yat Sen Univ, Inst Canc, Ctr Canc, Guangzhou 510060, Peoples R China

[4] Minist Educ, Key Lab Pesticides & Chem Biol, Guangzhou 510642, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 11期

关键词：

D O I：

10.7164/antibiotics.57.721

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new illudane sesquiterpenes, paneolic acid and paneolilludinic acid, along with a known antibiotic diterpene, pleuromutilin, were isolated from the mycelial solid cultures of Panaeolus retirugis. Their structures were elucidated on the basis of spectroscopic analysis. Both compounds exhibited antibacterial activity against Staphylococcus aureus, and paneolic acid showed cytotoxicity to HL60 cell with an IC50 of 18.9 mug/ml.

引用

页码：721 / 725

页数：5

共 9 条

[1]

Birch A.J., 1966, TETRAHEDRON, V22

[2] Pleuromutilins. Part 1: The identification of novel mutilin 14-carbamates [J].